Search
Now showing items 1-10 of 11
The p53-induced gene wig-1 : regulation of expression and role in embryonic development
(2003-11-21)
The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. ...
Xenobiotics-induced phosphorylations of MDM2
(2006-11-24)
The aim of the present study was to characterize the Mdm2 and p53 responses induced by DNA damaging xenobiotics and how these responses can be modified by non-genotoxic xenobiotics. During control conditions cellular levels ...
Factors influencing physical activity in patients with venous leg ulcer
(2009-11-20)
Background and Aim: Venous leg ulcer is a chronic condition characterized by a cyclical pattern of healing and recurrence leading to pain, disability, inactivity and reduced health. Physical activity is beneficial for ...
Neuromotor development and brain structure in children born extremely preterm
(2022-11-22)
Children born extremely preterm (EPT) are increasingly surviving but it is well known that they face a high risk of brain injury and neurodevelopmental impairments. The overall aim of the studies included in this thesis ...
Feeling the force : role of AmotL2 in normal development and cancer
(2019-03-21)
Cells that fabricate the body, dwell in a very heterogeneous environment. Self-organization of individual cells into complex tissues and organs at the time of growth and revival is brought about by the combinatory action ...
Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking
(2017-05-26)
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit ...
Development and application of competing risks and multi-state models in cancer epidemiology
(2023-02-20)
Competing risks and multi-state models allow us to study complex disease settings and answer composite research questions and should be used more widely in epidemiology. This thesis aims to explore the competing risks and ...
Shoulder and upper extremity impairments, activity limitation and physiotherapeutic exercise in women with rheumatoid arthritis : a biopsychosocial approach
(2000-05-04)
The aim of this thesis was to evaluate both specially-designed and commonly used instruments for measuring impairments, activity limitation and health-related quality of life (overall Sickness Impact Profile (SIP)). The ...
Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease
(2022-05-06)
Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed ...
Long-acting reversible contraception (LARC) after pregnancy and childbirth
(2023-02-17)
Background and aims: Unmet need of contraception is a global challenge. The need of additional visits to initiate contraception is found to be a barrier for postpartum and postabortion contraceptive care. The IUDs and the ...