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Clinical, histopathologic and genetic diagnosis in osteogenesis imperfecta and dentinogenesis imperfecta
(2004-01-23)
The aims of this thesis were to investigate (1) dental aberrations in a large sample of unrelated patients with different types and forms of OI, (2) degree of dentin dysplasia in relation to type and form of OI and clinical, ...
Prion processing and propagation in neuronal and dendritic cell culture models
(2004-10-22)
Prion diseases are rare neurodegenerative diseases, associated with a
conversion of a normal cellular protein, PrPC, into its misfolded and
partial protease resistant isoform, PrPSc. These diseases affect both
animals ...
Assessment of acetabular cup position with computed tomography
(2004-03-26)
fusion, the mean error of the angle between cup openings was 2.5° (range 0.3-5.3°, SD 1.5°), of the acetabular opening centerpoint 2.5 min (range 0.4-9.9, SD 2.8), and of the femoral component head was 1.0 min (0.7-1.8, SD 0.3) (study I). Using an over...
Analysis of viral and cellular gene expression patterns in cells latently infected with EBV by suppression subtractive hybridization
(2003-10-31)
Epstein-Barr virus is a ubiquitous γ-herpes virus and causes the self-limiting lymphoproliferative disease, called infectious mononucleosis. Its presence is associated with several malignancies, including Burkitt lymphoma, ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Life without thyroid hormone receptors
(2003-08-08)
expression in the absence and activation in the presence of T3, and iii) enzymatic control of the relative concentrations of the active thyroid hormone (T3) versus prohormone (T4) through deiodinase activity. There are also target genes that respond...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
The general aim of this thesis was to gain increased insight into the problem of local recurrences after breast conserving surgery for breast cancer. In a population-based cohort of 4,694 women with invasive breast cancer, operated in 1981 to 1990...
Cellular immunity and inflammation in atherosclerosis
(2001-11-09)
generates reactive aldehydes that modify proteins. Two important aldehydes are malondialdehyde (MDA) and 4-hydroxynonenal, which can form covalent adducts on proteins. To analyze the mechanisms for the activation of T cells by aldehyde-modified proteins...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
of ERK in cisplatin-induced apoptosis was studied in four melanoma cell lines. ERK activation was seen 4 h after cisplatin treatment. Inhibition of the pro survival ERK pathway resulted in different responses, from sensitizing to slightly protective...
Genetic studies of hypospadias
(2002-11-22)
Hypospadias is defined as an abnormal opening of the urethra on the underside of the penis. It is a frequently found malformation with an incidence of 3 per 1000 males. The aim of this thesis was to identify genetic and ...