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Outcome after surgery of congenital cataract
(2002-05-03)
The visual outcome in infants undergoing surgery for bilateral congenital cataract has improved considerably because of improved surgical methods and the realisation that early detection, allowing early cataract extraction ...
Metabolism of melatonin : with focus on the influence of cytochrome P4501A2
(2004-01-09)
mechanisms were unclear.
For that reason healthy individuals were given placebo, and two different
selective serotonin re-uptake inhibitors (SSRIs) - FLU and citalopram
(CIT) - on three separate occasions. 2-3) The CYP1A2 activity varies
considerably between...
Weight history, low birth weight, alcohol consumption and type 2 diabetes
(2003-02-21)
Type 2 diabetes is an increasing public health problem, currently affecting about 3-4% of the Swedish population. A worldwide increase in the prevalence of the disease has been demonstrated and preventive strategies are needed to turn this trend...
Toxicity of smokeless tobacco in human oral epithelium with emphasis on carcinogen metabolism and regulation of programmed cell death
(2002-10-10)
) transcripts were demonstrated including ]AL 1A2, 2C, 2D6, 2E1,
3A4/7 and 3A5. 'typical CYP substrates, including ethoxyresorutin,
methoxyresorufin and chlorzoxazone, were delectably oxidized in vitro and
metabolism of the tobacco-specific N-nitrosamine 4...
Mechanisms of activation of the hypoxia-inducible transcription factor 1a
(2002-04-05)
the involvement of HIF-1 alpha with transcriptional cofactors in regulating gene expression. We have shown that HIF-1 alpha conditionally interacts via two distinct transactivation domains with the coactivators CBP1/p300, SRC-1 or TIF2 in addition to the nuclear...
On the interaction between a neuromuscular blocking agent and regulation of breathing during hypoxia
(2003-11-14)
It was previously generally agreed that a mechanical train-of-four (TOF) ratio >0.70 represented an adequate recovery of respiratory function after neuromuscular blockade. Normal respiratory parameters at this level of ...
Allergic inflammation in children with pet allergy and asthma : mechanisms, markers and clinical consequences
(2002-05-10)
Immunological background: Allergic inflammation is a multiple-step process with many actors, where eosinophils and the release of their granula proteins play an important role. The recruitment of eosinophils is a crucial ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
Retinoids (vitamin A derivatives) are vital nutrients that regulate a variety of physiological processes, including embryonic development, postnatal growth, reproduction, cell differentiation as well as maintenance of the ...
Cataract from ultraviolet radiation
(2001-11-09)
Cataract is the major cause of low vision and blindness in the world.
Epidemiological and experimental studies link cataract to (solar)
ultraviolet radiation (UVR) exposure. Current safety limits of UVR
exposure are based ...