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Therapeutic myocardial angiogenesis and its pharmacological modulation
(2005-09-30)
Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of ...
Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by ...
The epidemiology of low back pain in the general population and after motor vehicle collisions : population-based investigations
(2004-11-23)
the
incidence and course of LBP episodes in the general adult population.
Papers I and IV are based on the same study population. A random sample
of 2,055 Saskatchewan adults received a health survey and 1,133 (55.1%)
returned completed questionnaires...
Diet and renal cell carcinoma
(2005-01-14)
as the major dietary patterns, assessed by self-administered food frequency questionnaire (FFQ), and risk of RCC. We identified 122 incident cases of RCC (ICD-9 diagnosis code 189.0) diagnosed between the return of the questionnaire at baseline (1987...
Early detection of Alzheimer's disease and dementia in the general population : results from the Kungsholmen project
(2004-09-08)
This doctoral thesis investigates early predictors of Alzheimer's disease
(AD) and dementia in the general population, and verifies the accuracy of
different syndromes of cognitive impairment for predicting progression ...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
) boosters in non-responders were retrospectively analysed. Seroprotection was achieved in 1,517/1,840 (82.5%) vaccinees. Among non-responders, two-thirds had no detectable antibodies and one-third had levels of 1-9 IU/L (hypo-responders). In the group...
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
55 patients were used in the experiments. RA and RARS cells showed significantly higher spontaneous initiator (caspase-8 and -9) and effector (caspase-3-like) activities than normal bone marrow (NBM). G-CSF inhibited Fasinduced caspase activity...
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(2005-05-27)
High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as ...
Impaired glucose tolerance in ischemic heart disease
(2005-11-18)
Background: Diabetes mellitus (DM) and impaired glucose tolerance test
(IGT) are well known risk factors for cardiovascular disease (CVD).
Individuals with IGT, a prediabetic state, are asymptomatic during many
years ...
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(2004-11-05)
Obesity has become an important health problem worldwide. It increases
the medical risks and affects daily living. Environmental factors such as
diet and sedentary lifestyle are likely to be the cause. In Sweden, the
number ...