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Design and synthesis of steroid mimetic libraries using solid phase techniques
(2004-09-10)
This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques.
In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure...
Disassembly and reassembly of the nuclear pore complex
(2006-09-22)
The nuclear pore complexes (NPCs) are multiprotein communicative channels spanning the nuclear envelope. In higher eukaryotes NPCs reversibly disassemble during mitosis into distinct nucleoporin subcomplexes. Some cell ...
Dietary supplements : trends, demographics and mortality among users
(2004-11-05)
%.
Validity for micronutrient intake (Spearman correlation coefficients)
increased by 13% (from 0.49 to 0.62), when nutrients from supplements
were included. The classification of micronutrient intake from the FFQ
into corresponding quintile in the 24-hour...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
increased by about 0.5-1 % MVE as a function of vibration at frequencies around 4-5 Hz, with the higher levels when the neck was flexed. Muscle activity was also affected by vibration magnitude, where lower-neck-muscle and trapezius activity increased...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
of periodontal bone loss of more than 30% of the root length was 3.5-fold and 4.3-fold elevated in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was 7.5-fold elevated in water...
Tobacco smoking and vertical periodontal bone loss
(2005-05-18)
study populations, Swedish musicians and a Saudi Arabian population. All participants had a full set of intra-oral radiographs including 16 periapical and 4 bitewing projections that were assessed with regard to presence or absence of vertical defects...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...
Cholinergic receptors in human prenetal brain : presence, distribution and influence of nicotine and ethanol
(2005-03-18)
Events early in life, including exposure to various compounds, may cause
disturbances in brain development. Both maternal smoking and alcohol
drinking during pregnancy can induce preand postnatal death, cognitive
and ...
Pharmacological and clinical studies of new ways to improve cytostatic treatment of acute myelocytic leukemia : in vitro and in vivo studies
(2005-02-18)
A/fludarabine. CdA was significantly more active than Ara-C (p<0.05) but not more than fludarabine. The cytotoxicity of CdA correlated strongly to fludarabine (r=0.82,p<0.0001) but less toward Ara-C (r=0.49,p=0.002). A significant number of Ara-C resistant cells...
Preoperative staging and radiotherapy in rectal cancer surgery
(2006-09-29)
Background: Rectal cancer affects approximately 2 000 people in Sweden every year. The overall survival rate is approximately 50% after five years. During the last decades the survival has increased and the local recurrence ...