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Immunogenicity of anti-leishmaniasis vaccines in man
(2003-12-26)
volunteers (ages 7-52) were screened for exposure to Leishmania. Of these 98 were negative for LST and had negative antiLeishmania antibodies. The drop out rate of this one and a half-year study was high. The LST conversion was in 4/13 and 3/7 volunteers...
Natural and induced immunity against the tumour-associated antigen, Ep-CAM
(2003-11-27)
The tumour-associated antigen (TAA), Ep-CAM is overexpressed on various human carcinomas, including colorectal carcinoma (CRC). TAAs or their immunodominant epitopes that are spontaneously recognised by the immune system ...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
products were more or less complex 1,3-benzoxazinones, one of which required X-ray crystallography confirm its structure. During the work on preparation of N-substituted derivatives of Aa, necessary for synthesis of 1,4-benzodiazepine-3,5-diones...
Factors affecting attendance at population-based mammography screening
(2002-01-11)
. Non-attendance was more likely among women who smoked regularly, had not visited a doctor in 5 years, had never had cervical smear tests, had never used oral contraceptives or hormone replacement therapy, never drank alcohol, and who reported no breast...
The human placenta : an angiographic study
(2003-04-25)
separate vessel in 112 placentas (85 %), a fenestration in 6 (5%) and a fusion in 3 (2%). In 10 the anastomosis was absent, in five of these due to a single umbilical artery. The anastomosis was wide in placentas in which the relative area supplied by each...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
, the kappa level for dysplasia being 0.44. Comparison of the frequency of bile duct dysplasia in livers from patients with PSC with and without CC showed dysplasia in 19% (5/26) of the cancer patients and in 0% (0/60) of non-cancer patients (p<0...
Adaptation to ischemia with special emphasis on nitric oxide
(2001-08-31)
Nitric oxide (NO) may play an essential role for maintenance of cardiac function and perfusion. Endothelial dysfunction of atherosclerotic vessels may aggravate cardiac ischemia/reperfusion injury. Adaptation to ischemia ...
Mild cognitive impairment neuroimaging markers for early diagnosis of dementia
(2003-09-12)
This thesis concerns the investigation of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single photon emission computed tomography (SPECT) and quantitative electroencepholography (qEEG).
In study ...
Effects of gravity and posture on the human lung
(2004-03-18)
subjects in whom acute lung insufficiency was induced by hypergravity. When exposing healthy subjects to 5 times normal gravity (5 G) in the human centrifuge, the arterial oxygen saturation was 84.6 + 1.2% (mean ± SEM) in the supine and 89.7 ± 1...