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A functional genomics approach to study prostate disorders
(2003-09-12)
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized ...
Toxin production in clostridium difficile
(2004-05-20)
Clostridium difficile is a is a Gram potential human pathogen. It causing symptoms ranging from mild C. difficile associated diarrhea (CDAD) to severe inflammation of the colon including pseudomembranous colitis and fulminant ...
Ultraviolet radiation and cornea
(2002-03-01)
Background: Acute exposure of the mammalian eye to UVR results in development of photokeratitis after a period of a few hours. Chronic exposure to UVR is associated with an increased risk of several corneal disorders, ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Life without thyroid hormone receptors
(2003-08-08)
Thyroid hormone (TH) has many important functions during development and in the adult individual. It reaches its target cells via the blood system and binds its receptor (TR) located within the cell nucleus where the ...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
, the kappa level for dysplasia being 0.44. Comparison of the frequency of bile duct dysplasia in livers from patients with PSC with and without CC showed dysplasia in 19% (5/26) of the cancer patients and in 0% (0/60) of non-cancer patients (p<0...
Quality of life in patients with malignant blood disorders : a clinical and methodological study
(2002-10-25)
The overall aim of this thesis was to evaluate and, improve measurements of, health-related quality of life (HRQL) in patients with malignant blood disorders. Patients undergoing autologous stem cell transplantation (SCT), long-term (>5 years...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
We have investigated the association of the humoral immune factors
circulating immune complexes (CICs) and autoantibodies against
cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic
vascular diseases.
In ...
On prognostic and treatment predictive factors in early stage breast cancer
(2002-05-03)
Breast cancer is the most common malignant tumor in Swedish women and the incidence is increasing with 1-2% per year in the Stockholm area. A subgroup of patients is women diagnosed with primary inoperable disease. This ...
A study of b-secretase cleaved Alzheimer amyloid precursor protein
(2002-04-05)
Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). ...