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Pathogenetic studies of adjuvant-induced arthritis
(2002-11-15)
Rheumatoid arthritis (RA) is a disabling chronic inflammatory disease, presumably autoimmune, that progressively destroys peripheral joints. The etiopathogenesis remains largely unknown, and an understanding of disease ...
Cloning and characterization of a p-53-inducible gene, WIG-1
(2001-11-27)
technique. Two mouse wig-1 transcripts of 7.6 kb and 2.2 kb were detected in Northern analysis. The 2.2 kb mouse wig-1 transcript was suggested to arise due to alternative polyadenylation and encodes the same zinc finger protein as the 7.6 kb transcript...
Studies on immunological mechanisms of induced arthritis in the rat
(2002-11-22)
Experimental arthritis induced with adjuvants shares many features with
the human autoimmune disorder rheumatoid arthritis (RA). The use of
arthritis models is therefore a relevant approach in the search for
pathogenic ...
A role for NK cells in innate immunity against human leishmaniasis
(2003-08-15)
Leishmaniasis is a group name for a spectrum of diseases caused by intracellular protozoa belonging to the family Leishmania. The parasites has been widely used as a tool to study the Th1 / Th2 paradigm of resistance and ...
Growth of parathyroid glands : genetic and functional aspects
(2003-11-21)
Ca2+ is an essential ion with a variety of important functions in the body and it is crucial that the Ca2+ levels are precisely regulated. One of the hormones regulating these processes is parathyroid hormone (PTH) secreted ...
Medium chain dehydrogenases/reductases : alcohol dehydrogenases of novel types
(2003-10-03)
The medium chain dehydrogenase/reductase (MDR) superfamily is separated into at least eight families, of which the dimeric alcohol dehydrogenase (ADH) is one. Including species variants, close to 1000 MDR forms have been ...
Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures
(2004-03-26)
Skeletal muscle is an insulin sensitive organ and plays a major role in
whole body electrolyte and substrate homeostasis in the post prandial
state. Impaired insulin action in skeletal muscle may lead to the
pathological ...
On the role of complement activation following traumatic brain injury
(2004-04-27)
Traumatic brain injury (TBI) is one of the leading causes of early death and disability among young people in the industrial world. The final clinical outcome in terms of morbidity/mortality is not only related to the ...
Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity
(2002-05-22)
Studies of animal models of type 2 diabetes mellitus implicate that impaired insulin signal transduction to glucose transport accounts for whole body insulin resistance in skeletal muscle and adipose tissue. The overall ...
Implantable devices in heart failure : studies on biventricular pacing and continuous hemodynamic monitoring
(2002-09-13)
Chronic heart failure is a highly symptomatic syndrome associated with increasing prevalence, frequent hospital admissions and high treatment costs. Despite recent advances in drug therapy, morbidity and mortality are still ...