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Occupational exposure to electromagnetic fields and chronic diseases
(2003-11-21)
This thesis consider two exposures from the electromagnetic spectrum extremely low-frequency magnetic fields (ELF MF) and ultraviolet (UV) radiation. ELF MF are the lowest and UV radiation ranges among the highest frequencies ...
Genetic differences in neuropathy and opioid responses in rats
(2003-11-28)
The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic ...
T cell production of cytokines, neurotrophins and MHC regulation in autoimmune neuroinflammation
(2002-05-24)
encephalitogenic T
cells use the TCRBV8S2 chain. Production of IFN-gamma selectively
occurred in this TCRBV8S2+subset derived from both the CNS and the
periphery. Furthermore, encephalitogenic TCRBV8S2+ T cells infiltrating
the CNS produced higher amounts of IFN...
Proinsulin C-peptide : membrane interactions and intracellular signaling
(2004-05-13)
effects by binding to a
G-protein coupled receptor, subsequently activating Ca 2' and
MAPK-dependent intracellular signaling pathways and eventually stimulates
Na+,K+-ATPase and eNOS. However, the precise molecular mechanisms of
C-peptide action...
Population-based studies of body mass index, overweight and systolic blood pressure among Swedish young men
(2002-08-30)
and overweight and systolic blood pressure in young adulthood on the other. Specific aims were to: 1) study time trends and socio-economic differences in body mass index and overweight among young men over the last decades; 2) study the occurrence of overweight...
Novel neurophysiological monitors of the transition from wakefulness to loss of consciousness during anaesthesia
(2003-09-12)
and awareness of a loud auditory stimulus were evaluated.
Study 2 investigated how nitrous oxide influenced BIS and how well BIS could distinguish between wakefulness and loss of consciousness with nitrous oxide. Nitrous oxide was administered both as a sole...
Analysis of viral and cellular gene expression patterns in cells latently infected with EBV by suppression subtractive hybridization
(2003-10-31)
. Combining DOP-PCR with SSH enabled us to perform subtraction hybridization on cDNAs isolated from resting B cells and on its freshly (2-week) EBV-infected counterpart. The identified differentially expressed genes were confirmed by ratio PCR and a novel...
On prognostic and treatment predictive factors in early stage breast cancer
(2002-05-03)
Breast cancer is the most common malignant tumor in Swedish women and the incidence is increasing with 1-2% per year in the Stockholm area. A subgroup of patients is women diagnosed with primary inoperable disease. This group constitutes about 15...
Carbon dioxide de-airing in cardiac surgery
(2004-01-09)
: In a cardiothoracic wound model, a full-size torso, the degree of air displacement achieved by the gas-diffuser, was compared with that of a 2.5 mm. open-ended tube, a 6.35 mm open-ended tube, a multiperforated catheter, and a gauze sponge, respectively...
Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...