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Mortality in epilepsy : epidemiological studies with emphasis on sudden unexpected death and suicide
(2002-01-25)
patients who had epilepsy surgery (ES) treatment during 1990-98 (N=596) were identified through the Swedish Epilepsy Surgery Register and followed in the cause of death register until the end of 1998. The SMR for all causes of death was 4.9 (2.7-8.3 95% Cl...
Transcriptional mechanisms directing terminal differentiation of B lineage cells
(2002-11-01)
regulator of HS1,2 function. In subsequent
studies the transcriptional corepressor Groucho related gene 4 (Grg4) was
found to play a regulatory role in modulating the function of Pax5, PU.1
and Oct-2. Further characterization and identification of likely...
Hypoxia inducible factor 1alpha : molecular mechanisms of regulation
(2002-05-24)
Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to ...
Etiology of gastroesophageal reflux
(2004-04-16)
-Trondelag, Norway. Among the 58,596 persons included in this study 15,233 (26%) had experienced minor symptoms of heartburn or regurgitation while 3,154 (5.4%) had severe symptoms of heartburn or regurgitation. Among women there was a gradual increase...
Exercise and outcome measures in patients with polymyositis and dermatomyositis
(2003-08-22)
Polymyositis (PM) and dermatomyositis (DM) are chronic idiopathic inflammatory myopathies (IIM) which are clinically characterized by symmetrical proximal muscle weakness, fatigue, myalgia and extra- muscular involvement. ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Mild cognitive impairment neuroimaging markers for early diagnosis of dementia
(2003-09-12)
This thesis concerns the investigation of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single photon emission computed tomography (SPECT) and quantitative electroencepholography (qEEG).
In study ...
Biocomputational studies on protein structures
(2002-08-16)
respiratory function proteins (MRF), acetyl-CoA reductases of fatty acid synthases (ACR), and leukotriene B4 dehydrogenases (LTD). The two remaining families, with polyol dehydrogenases (PDH) and quinone reductases (QOR), are also distinct but with variable...
Retinoids in experimental neuroblastoma therapy
(2003-01-24)
Retinoids are analogues of vitamin A, with documented activity against various malignant cell types. Neuroblastoma is a childhood tumour of the sympathetic nervous system that shows a complex clinical and biological ...
Aortic valve replacement with stentless bioprostheses : prospective long-term studies of the Biocor and the Toronto SPV
(2002-03-22)
groups, respectively, and long-term actuarial survival at 7 years was 59%±6% and 90%±2%. There was no difference in survival between the BS valve patients and the expected survival for the age- and gender- matched comparison population supplied...