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NF-kB in epidermal signal transduction and tumor development
(2002-11-15)
The transcription factor NF-kappaB has been extensively studied since its discovery. NFkappaB has been shown to be invoved in many cellular processes in many different cell types. However, its functions in skin physiology ...
Pathogenetic studies of adjuvant-induced arthritis
(2002-11-15)
of injection.
In squalene-induced arthritis the non-major histocompatibility complex (non-MHC) genetic contributions are mainly derived from two regions, the Oia2 quantitative trait locus (QTL) on rat chromosome 4 and the Oia3 QTL on rat chromosome 10...
Immunogenetic studies in autoimmune endocrine diseases
(2003-11-25)
autoimmune process. The strongest genetic association identified is that with HLA class II genes located on the short arm of chromosome 6. It is well known that both HLA DRB1*04-DQA1*0301DQB1*0302 (DR4-DQ8) and DRB1*03DQA1*0501-DQB1*0201 (DR3-DQ2...
Long-term outcome of renal transplantation in childhood
(2003-01-31)
The aim of this thesis was to evaluate the long-term results of renal transplantation in children at Huddinge University Hospital, with special reference to outcome. We therefore evaluated the course of events in children ...
Immunogenicity of anti-leishmaniasis vaccines in man
(2003-12-26)
neither did it modulate the IFN-gamma, IL-4, IL-10 and IL-12 responses of healthy Sudanese volunteers to Leishmania antigen.
The immunogenicity of the ALM + BCG vaccine was evaluated in a leishmaniasis endemic area in eastern Sudan. Five hundred healthy...
HMBG1 as a proinflammatory mediator in arthritis
(2003-05-02)
Proinflammatory cytokines are central in the pathogenesis of chronic arthritis and a new generation of therapeutics blocking TNF or IL-1 has improved outcome for many patients with inflammatory joint diseases. This thesis ...
Effects of influenza A virus infections and interferon-gamma on synapse formation and function in hippocampal neurons in culture
(2004-09-03)
that persisted even after clearance of the infection in the culture 4) Neuronal networks exposed to INF-gamma during the peak of synapse formation can develop an imbalance between excitatory and inhibitory synaptic activities, which become evident after a latency...
Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function
(2003-09-11)
and maintenance of a reduced body weight. In study VI short-term treatment with oral diazoxide improved important parameters of beta cell function in 4 male and 4 female obese subjects with type 2 diabetes, indicating beneficial effects on beta cell function...
Depot-neuroleptics for better or for worse : patients' and nurses' experiences of long-term treatment in psychiatric outpatient care
(2003-05-12)
) "Inability to advocate patients best interest occurs when nurses feel they are at a disadvantage"; 3) "Accommodative interactions occur when the nurses are able to respond to the patients expressed needs" and 4) "Acceptable advocacy occurs when physicians...
Estrogen receptor b in the urogenital tract of both male and female
(2002-05-24)
induced CRISP (cysteine-rich secretory protein) and this induction was inhibited by both antiestrogen and antiandrogen; and (4) The estrogen induced increase in proliferation rate in the uterus (measured by BrdU labelling), was blocked by both antiestrogen...