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HMBG1 as a proinflammatory mediator in arthritis
(2003-05-02)
Proinflammatory cytokines are central in the pathogenesis of chronic arthritis and a new generation of therapeutics blocking TNF or IL-1 has improved outcome for many patients with inflammatory joint diseases. This thesis ...
Mutational analyses of the tumor suppressor gene Patched1 : role in non-melanoma skin cancer and nevoid basal cell carcinoma
(2008-05-02)
Skin cancer is the most common cancer in Western countries, with a
rapidly increasing incidence. The majority of these tumors are
non-melanoma skin cancer (NMSC). The most common NMSC is basal cell
carcinoma (BCC) ...
Statistical methods for long-term follow-up of infectious diseases
(2014-02-21)
The overall aim of this work has been to investigate methodological issues connected to long-term follow-up of infections diseases. The work extended to prevalent cohorts in general. The common denominator for the main ...
Statistical methods for the detection and analyses of structural variants in the human genome
(2012-08-16)
Structural variations (SVs) are an important and abundant source of variation in the human genome, encompassing a greater proportion of the genome as compared to single nucleotide polymorphisms (SNPs). This thesis investigates ...
Improving animal models to understand gene regulation in human diseases
(2021-10-29)
The role of animal models in understanding biological processes and their dysregulations in humans is imperative and established in the research community. While extensive resources and knowledge on the genetic information ...
Social differentials in health-related non-employment and poverty : studies on consequences of limiting longstanding illness, musculoskeletal and mental disorders
(2015-10-01)
The overall aim of the thesis is to increase knowledge on social differentials in employment and income consequences among persons with chronic disease. The studies were conducted in Sweden and different policy context ...
Medical and nurse students' perspective on learning in acute care
(2016-08-25)
Background: Medical and nurse students’ professional training takes place in a complex and rapidly changing health care setting. Workplace learning in this context have a considerable potential to contribute to the development ...
Structure-function studies of plasminogen activator inhibitor-1
(1998-11-20)
Plasminogen activator inhibitor-I (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and urine-type plasminogen activator (uPA). High plasma levels of PAI-1 correlate to thrombotic ...
Biomedical factors in the risk and prognosis of amyotrophic lateral sclerosis
(2022-03-28)
Amyotrophic lateral sclerosis (ALS) is a relatively rare but incurable and relentlessly progressive neurodegenerative disease, characterized by motor neuron loss in the brain and spinal cord. Majority of patients die within ...
Involving concerned significant others in the treatment of problem gambling
(2019-10-18)
Background: Problem gambling (PG) is a worldwide phenomenon that affects both gamblers and their concerned significant others (CSOs). Apart from financial difficulties, problem gambling is associated with disrupted ...