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Changes in mitogen-activated protein kinase phosphorylation and inorganic phosphate induced by skeletal muscle contraction
(2002-10-04)
in the phosphorylation of two MAP kinases, MAPK erk 1/2 and MAPKK mek1/2, were identified in response to one-leg exercise in humans. In isolated rat muscle, isometric contractions induced a similar increase in phosphorylation of MAPKerk1/2 in slow- and fast...
Allergen-induced airway reactions in the pig in vivo : inflammatory mediators as targets for asthma therapy
(2002-03-01)
induced a significant rise in BVC when given i.v. due to NO-mediated vasodilatation. Aerosol challenges with ET agonists resulted in a decrease in BVC, probably due to direct ETA/ETB2-mediated effects on vascular smooth muscle. This direct vasoconstrictive...
Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system
(2002-05-17)
Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). ...
Altered gene expression in the human airways during oxidative stress
(2003-01-10)
A549 lung epithelial cell line to sub-toxic levels of hydrogen peroxide caused sustained arrest in cell cycle progression and activation of apoptotic events, including activation of caspase-3 and the augmentation of TRAIL-dependent caspase-3...
Immunological studies of adenoids in children : relation to atopy
(2003-10-03)
of the cytokines IL-2, IL-4 and IFN-gamma after non-specific stimulation, presence of IgE+ cells and IgE+ plasma cells. Peripheral blood lymphoid cell populations and subpopulations were also examined and related to the same populations in adenoids.
RESULTS...
Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity
(2002-05-22)
Studies of animal models of type 2 diabetes mellitus implicate that impaired insulin signal transduction to glucose transport accounts for whole body insulin resistance in skeletal muscle and adipose tissue. The overall aim of the present thesis...
Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene
(2003-05-23)
for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The present study was undertaken in an attempt to elucidate the mechanism of activation of the CYP1A1 gene by several compounds that recently have been reported...
Noradrenergic augmentation strategies in the pharmacological treatment of depression and schizophrenia : an experimental study
(2002-08-23)
The pharmacological treatment of depression and schizophrenia, two major psychiatric disorders, is largely based on modulation of central monoaminergic neurotransmission. However, currently available pharmacological treatment ...
Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids
(2002-05-03)
to contribute to hyperalgesia and allodynia. The cholecystokinin (CCK) gene- expression and CCK2-receptor gene-expression in dorsal root ganglion (DRG) cells is upregulated after sciatic nerve transection (axotomy). Since CCK acts as an anti-opioid peptide...
Role of mast cell-derived mediators for leukocyte / endothelium-interactions and microvascular mechanisms in inflammation and in anaphylaxis
(2003-02-13)
The overall objective of this thesis was to study the roles of mast cell-derived mediators for leukocyte/endothelium interactions and microvascular mechanisms in inflammation and in anaphylaxis, using mast cell-deficient ...