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Regulation of mitochondrial transcription and mtDNA copy number in mammals
(2003-05-02)
Functional mitochondria are essential for wellbeing of the cell and the whole organism. Gene expression from the mitochondrial genome (mtDNA) is indispensable for oxidative phosphorylation, but also for the replication of ...
Longitudinal studies of human papillomavirus infection : with special reference to screening for cervical cancer and treatment of CIN
(2003-10-03)
followed with repeated testing for cervical HPV DNA. 85% of the women were HPV DNA positive before treatment, but I year later only seven women (9%) were positive for the same HPV type. Most women had cleared their infection at 3 months, suggesting that HPV...
Structure and function of hepatic cytochromes P450 : implications for drug development
(2002-11-25)
polymorphic genes.
Various in vitro systems like homology models of P450 enzymes,
recombinant enzymes, liver microsomes, hepatocyte primary cultures and
liver slices were compared with respect to predictability of in vivo
metabolism of 3 different drugs...
Postoperative nausea and vomiting in women : an unglamorous aspect of anaesthesia
(2002-08-23)
anaesthetic regimens were studied with respect to the incidence of PONV and to identify potentially favourable anaesthetic combinations with regards to PONY The antiemetic effects of the 5-HT3 receptor antagonist tropisetron, intra-operative positive...
Leukocyte-endothelial interactions in arteries in vivo : a new concept in the study of physiology and disease in large blood vessels
(2001-11-23)
Pathophysiological events in large blood vessels contribute to immense
morbidity and mortality in our society. A major clinical problem is a
disease known as atherosclerosis. It involves a slow inflammatory
deposition ...
Studies of presenilin function in neurodegeneration and in human embryonic CNS during development
(2004-05-21)
-2
and Notch-4 were not seen in the CNS at any age and in any region
studied. Notch-3 expression was restricted to endothelial cells in blood
vessels of both developing cortex and spinal cord. Jagged-1 was found
sporadically in cells around...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
, the kappa level for dysplasia being 0.44. Comparison of the frequency of bile duct dysplasia in livers from patients with PSC with and without CC showed dysplasia in 19% (5/26) of the cancer patients and in 0% (0/60) of non-cancer patients (p<0...
Morbidity in Ménières disease : aspects on quality of life and triggering factors
(2002-11-22)
or vestibular neurectomy) was most beneficial to patients with Menieres disease; 2. To evaluate health-related quality of life issues from a general and disease specific perspective; 3. To find if stress can trigger attacks of Menieres disease; and 4. To propose...
Effect of pharmacological treatment of serotonergic function in depression
(2002-05-03)
parameters studied in this work were the active 5-HT uptake, the [3H]paroxetine binding to the 5-HT transporter and the [3H]LSD binding to 5-HT2A receptors. Since direct studies of the living human brain are associated with great methodological difficulties...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 are positively while DQ6...