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Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism
(2002-11-15)
CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of procarcinogens...
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
Pharmacogenetics of drug metabolising enzymes has been well studied in Caucasians and Asians, but relatively little in Africans. The aim of this thesis was to investigate the molecular genetics of drug metabolising enzymes, in particular CYP2D6, CYP...
Nephrotic syndrome in children : functional, morphological and therapeutical aspects
(2003-03-21)
; respectively) and ERPF (from 521 to 468 and 581 to 398 ml/min per 1.73m2, respectively). In the MCNS patients, the GFR normalized after cessation of treatment in 4 patients, who have had renal function tests after CsA treatment. Both groups responded well to Cs...
Differential expression pattern of CEACAM1 isoforms in polarized epithelial cells : it's regulation and some functional consequences
(2004-01-16)
dominated.
We found that tyr515 has a crucial role for the lateral localization of
CEACAM1-L and that the lysine residues 519-521 as well as ser503 also are
important for the steady-state lateral localization. We also demonstrated
that both pervanadate...
Pathophysiology of subarachnoid hemorrhage in the rat
(2003-08-08)
with the view that inflammation caused brain damage, we found a marked overlapping between areas with dying cells and those with inflammation. Using in situ hybridization, a CBF-dependent early downregulation of the hippocampal NR2A, NR2B and NR3B subunit m...
Health care financing in China : equity in transition
(2002-08-12)
The aim of the thesis is 1) to assess equity in the provision, financing and utilization of health services in the study counties, after the launching of the Chinese health reform, in relation to income and health status, 2) to assess equity...
Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans
(2003-05-16)
Gene expression in eukaryotic organisms commences with the synthesis of a precursor RNA, which has to be extensively processed to yield a mature RNA molecule. In addition to processing, the RNA molecule needs to associate ...
Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment
(2003-12-26)
for an
adequate multivariate risk factor analysis.
CMV-retinitis (CMVR) has previously been a rare complication after SCT.
In a European multicentre study on 30 patients developing CMVR after SCT,
it was shown that 1.2% of all patients transplanted...
Development of working memory, speech perception and auditory temporal resolution in children with attention deficit hyperactivity disorder and language impairment
(2002-11-08)
Speech perception (SP), verbal working memory (WM) and auditory temporal resolution (ATR) have been studied in children with attention deficit hyperactivity disorder (ADHD) and language impairment (LI), as well as in ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced...