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Pathogenesis of myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in DBA/1 mice
(2001-12-21)
).
Investigation of CD4 cell deficient mice (CD4-/-) and CD8 cell deficient mice (CD8-/-), as well as of wild type DBA/ 1 mice depleted of either CD4+ T cells or CD8+ T cells, highlighted the role of CD8+ T cells in MOG-induced EAE. Co-administration of PT appeared...
Role of toll-like receptors in host responses to mucosal bacterial infections
(2002-11-15)
. pylori was strictly dependent on the presence of the cag pathogenicity island. We found that H. pylori induced a different cytokine response in primary cells than in gastric cell lines. While gastric cell lines exclusively produced IL-8 in response to H...
Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells
(2003-05-16)
Lipopolysaccharide (LPS) is a well-characterized pathogen-associated molecule found primarily as a constituent of the outer membrane of Gram-negative bacteria. LPS is known to act on different cell types in a pleiotropic ...
Skin cancer prevention : readiness to change sun-related behaviours
(2004-04-02)
The general aim of this thesis was to collect data relevant for skin
cancer prevention and to investigate the applicability of the
Transtheoretical Model for sun-related behaviour. Also, to assess the
readiness to change ...
Intravasal microdialysis as a novel technique to monitor metabolism in myocardial ischemia and critical illness
(2003-05-07)
Rapid detection of post-operative myocardial ischemia is of great value in the treatment of patients undergoing cardiac surgery. With the methods readily available in modem thoracic intensive care units post-operative ...
Trinucleotide repeats and neuropsychiatric phenotypes
(2001-11-02)
loci. CTG18.1 expansions were more frequently seen in patients as compared to healthy individuals (odds ratio 2.6-2.8), and their size correlated inversely with age-of-onset. The allele distribution at ERDA1 was not significantly different between...
Deciphering mechanisms of transcriptional activation and repression in B lymphocytes
(2004-05-14)
During the course of evolution, our immune system has developed, to defend us against infections, a diverse number of specialized cell types. Immunoglobulin producing B lymphocytes are produced by the differentiation of ...
Neurotoxicity of methylmercury : analysis of molecular mechanisms and behavioral alterations
(2002-04-05)
MethyImercury (MeHg) is a global pollutant that is toxic for the nervous system, especially during development. Contaminated fish is the main route of human exposure. Recent studies have indicated that neurological alterations ...
Description and prediction of clinical radiosensitivity : emphasis on normal tissue reactions
(2004-02-27)
studied the long-term
incidence of clinical hypothyroidism in 308 evaluable patients. The
median follow-up in this study was 4.2 years. The incidence of clinical
hypothyroidism was 17%, and the median time to development of
hypothyroidism was 1.8 years...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
-99 according to an extensive investigational protocol. A presumptive explanation of the stillbirth was established in 91% of the cases. The most common factors associated with intrauterine fetal death could be identified as infections (24%), placental...