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Pain-related fear and movement : implications for physiotherapy and public health
(2003-01-17)
of catastrophizing were related to ratings of pain with an increased risk by 1.8. Furthermore fear-avoidance beliefs increased the risk of the inception of a new episode of pain by 2 and catastrophizing increased the risk by 1.5. The risk of a lower physical function...
On the role of SAP kinase pathways in cellular responses to cancer treatment
(2003-03-21)
oncogenic Ras influences the sensitivity of cells to cisplatin is clinically important. This was studied in FR3T3 fibroblasts and sublines transformed by 12V-H-ras. In response to cisplatin, FR3T3 cells arrested in G2, while the ras-transformants accumulated...
Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
tested as adjuvants of genetic immunizations with HIV-1 genes, it was demonstrated that the Th1 pattern of a primary immune response could be switched toward an enhanced Th2 response, by plasmids expressing the secreted form of mGM-CSF or by recombinant m...
Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis
(2004-05-06)
both MS patients and HCs. IFN-beta induced Th2-driving DCs, which produced increased amounts of IL-10 and reduced amounts of IL-12 as compared to control DCs. Accordingly, IFN-beta-treated DCs, when cocultured with MNCs from HCs, reduced the production...
Clonidine in paediatric anaesthesia : pharmacokinetic and pharmacodynamic aspects
(2002-04-12)
Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. Descending posjunctional noradrenergic antinociceptive...
Immune mechanisms in atherosclerotic vascular disease
(2002-05-14)
of low-secretory allele A1 of TNF alpha to RA. The severity of RA was influenced by carriage of high-secretory allele A2 of TNF alpha. Allele AI of TNF alpha was associated to development of stroke in hypertensive male patients, indicating that males...
Method development for analysis of 8-oxodG as a biomarker for oxidative stress
(2001-11-22)
Oxidative damage to DNA gives oxidation of DNA bases and strand breaks
that can cause mutations leading to cancer. Various forms of agents are
capable of oxidising DNA in vivo including peroxides, singlet oxygen and
UV- ...
Life without thyroid hormone receptors
(2003-08-08)
. This hormone-mediated gene regulation is a finely tuned interplay of numerous parameters. These include i) usage of several isoforms of receptors (TRa1, TRb1, TRb2, TRb3) encoded for by two distinct genes, ii) receptor-mediated repression of target gene...