Search
Now showing items 1-10 of 118
The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
(2003-08-08)
Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media and respiratory tract infections. Its lipopolysaccharide (LPS) molecule, an outer membrane component, is a major virulence factor of NTHi. The ...
Bronchoalveolar lavage and serum protein patterns in healthy individuals and sarcoidosis patients : a proteomics approach
(2004-01-23)
The etiology of sarcoidosis remains unknown. Although biochemical changes
are frequently observed in sarcoidosis, the problem of finding distinct
biomarkers remains. Only a few markers are defined in this disease. ...
Respiratory drive assessment : an evaluation of the breath-by-breath occlusion pressure method in man
(2002-08-22)
patients with nocturnal hypoxemia preserve their drive and chemosensitivity unaltered in at least one year without development of daytime hypoxemia. 3) Growth hormone profoundly improves the hypoventilation and chemosensitivity in Prader-Willi patients...
Models for infections in immunodeficiency
(2002-10-25)
regarding systemic disease, 3) humoral immunity is involved in the pathogenesis of pulmonary lesions, 4) proinflammatory cytokines, locally produced in the chondrocytes, may contribute to the aetiology of Mycoplasma-associated arthritis, 5) different genetic...
Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism
(2002-11-15)
CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of ...
Structural studies of bacterial carbohydrate antigens with focus on oral commensal bacteria
(2002-08-15)
90% of the total number of cells in the human body consist of the normal
bacterial flora. These bacteria are mostly not harmful and, indeed, even
beneficial as long as they remain physiologically outside the body, e.g.,
within ...
The role of galanin in chronic pain mechanisms
(2002-11-29)
The general aim of these studies is to further elucidate the role of
galanin in pain mechanisms. We have utilized normal and genetically
modified animals and a variety of techniques. In order to use genetically
modified ...
In vitro studies on the biosynthesis and reduction of ubiquinone
(2003-03-21)
This thesis concerns the role of ubiquinone, the only endogenously synthesised lipid soluble antioxidant, in the cellular defence against peroxidation of proteins and lipids.
The aims of the present investigations ...
Structural studies of some bacterial polysaccharides and extension of a method for lipid A cleavage
(2002-09-13)
The focus of the work presented in this thesis has been to study the
structures of the capsular polysaccharide from Serratia marcescens
O14:K12, and the O-antigen polysaccharides from Hafnia alvei strain 10457
and Vibrio ...
Factors associated with healing of periradicular lesions
(2003-01-24)
Healing of periradicular lesions is a complex process. This thesis addressed some factors of importance to the outcome, namely treatment options and host response in cases of refractory lesions, levels of pro-inflammatory ...