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T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses
(2002-11-15)
Immunodominance is a process in which the immune response focuses on one
or a few of all potential epitopes that exists within an antigen. The
mechanisms for immunodominance have not yet been determined. The work
described ...
Rectal cancer : staging, radiotherapy and surgery
(2003-05-02)
In Sweden, about 1800 patients are annually diagnosed with adenocarcinoma of the rectum. Surgery remains the major primary treatment. Adjuvant radiotherapy and total mesorectal excision (TME) are two major achievements in ...
Cloning and characterization of canine sulfotransferases
(2003-10-10)
.
The canine SULTs investigated display typical substrate specificity of the SULT1 family i.e. cSULT1B1 sulfates a-naphthol, p-nitrophenol (PNP) and thyroid hormones but not dopamine and b-estradiol (E2); cSULT1D1 sulfates a-naphthol, PNP, dopamine...
Vibro cholerae O139 : identification, characterization and vaccine strategies
(2003-10-24)
Cholera is an acute dehydrating diarrheal disease, and epidemics as well as pandemics of cholera are a major health problem in developing countries and cause many deaths each year, especially in children. Cholera is caused ...
Case-crossover studies of the triggering of disease : myocardial infarction and Ménières disease
(2003-05-07)
-referent study including all cases of first-time MI (n=2,246) occurring in Stockholm County from 1992 to 1994; the Onset study, a case-crossover study of all eligible nonfatal cases (n=699) in SHEEP 1993 to 1994; and, the study of triggers of attacks of Ménières...
HMBG1 as a proinflammatory mediator in arthritis
(2003-05-02)
Proinflammatory cytokines are central in the pathogenesis of chronic arthritis and a new generation of therapeutics blocking TNF or IL-1 has improved outcome for many patients with inflammatory joint diseases. This thesis ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
) on this process, a series of PGs were analyzed by semi quantitative reversed transcriptase polymerase chain reaction. The cells with epithelial phenotype showed increased expression of syndecan-2, syndecan-4 and hyaluronan synthase, and fibroblast-like cells...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...
Effect of pharmacological treatment of serotonergic function in depression
(2002-05-03)
parameters studied in this work were the active 5-HT uptake, the [3H]paroxetine binding to the 5-HT transporter and the [3H]LSD binding to 5-HT2A receptors. Since direct studies of the living human brain are associated with great methodological difficulties...