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Use of primary human hepatocytes for the elucidation of bile acid synthesis
(2003-01-03)
was defined in the hepatocytes including 7alpha, 12alpha, 27-trihydroxy-4-cholesten-3 -one, 7alpha,12alpha-dihydroxy-3-oxo-4-cholestenoic acid and 7alpha,12alpha-dihydroxy-3oxo-5beta-cholanoic acid as intermediates.
· The oxysterol 24S...
From data to decision : a case study of controversies in cancer risk assessment
(2002-11-01)
the chlorinated solvent trichloroethylene (CAS no. 79-01-6). The purpose of the present study is to discuss (1) why risk assessors come to different conclusions, (2) how scientific data are used in risk assessment, and (3) how scientific uncertainty is handled...
Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes
(2003-10-24)
The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to drug metabolism, in particular CYP3A4. responsible for the metabolism of a majority of drugs being metabolized in order to be excreted. There is a...
Human ovarian follicle recruitment : an in vitro approach
(2004-03-17)
Following the first reports of successful cryopreservation of human
ovarian tissue, the freezing and banking of such tissue has become common
practice worldwide for the preservation of fertility. Patients include
those ...
Deciphering mechanisms of transcriptional activation and repression in B lymphocytes
(2004-05-14)
regulated. Oct1 and Oct2, by altering their conformation upon binding to different cis sequences can differentially associate with the transcriptional co-repressor Grg4. A second method of complex formation with Grg4 is witnessed in the 3' enhancer...
Blood saving in orthopaedic surgery
(2002-05-10)
509 (316) m] compared to 775 (316) m] in tile supine group (p<0.001).Total blood loss was also lower 1273 (458) ml in the lateral group vs. 1472 (407) mI in the Supine (p<0.05). Reduced hydrostatic blood pressure in the wound and hence reduced bleeding...
Proteins influencing the integrity of meiotic chromosome dynamics
(2002-08-09)
that include the AE (formed by two meiosis-specific proteins, SCP2 and SCP3) and a second protein complex, composed of cohesins, which promotes sister chromatid pairing. Inactivation of SCP3 in male mice abolishes AE formation, resulting in chromosomal pairing...
Structure and function of hepatic cytochromes P450 : implications for drug development
(2002-11-25)
polymorphic genes.
Various in vitro systems like homology models of P450 enzymes,
recombinant enzymes, liver microsomes, hepatocyte primary cultures and
liver slices were compared with respect to predictability of in vivo
metabolism of 3 different drugs...
The loss of a husband to cancer : additional and avoidable psychological traumata
(2003-05-07)
of the prostate 1996 or of the urinary bladder 1995 or 1996, after a minimum disease duration of 3 months. All their surviving widows or partners (n=506) who were alive on the 1" of April 1999 and were 79 years or younger were contacted and compared to an age...
Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids
(2002-05-03)
Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal ...