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The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
(2003-08-08)
Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media and respiratory tract infections. Its lipopolysaccharide (LPS) molecule, an outer membrane component, is a major virulence factor of NTHi. The ...
Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
(2002-02-08)
than those of PBDEs. Among the PBDEs, 2,2',4,4'-tetraBDE (BDE-47) was the predominant congener in breast milk, adipose tissue, matemal and cord blood, while in liver samples 2,2',4,4',5pentaBDE (BDE-99) occurred at similar concentrations as BDE-47...
Crystallographic studies of gluconate kinase
(2001-11-23)
and 2.4 A resolution, respectively. There is a conformational change upon binding of ATP. The NMPbind and LID move away from the active site rather than closing into the active site to protect the ATP from hydrolysis as normally observed in this family...
Protein modification with hydrophobic prenyl groups in malignant cells
(2001-10-19)
Mevalonate (MVA) is the key intermediate in the isoprene synthetic
pathway leading to the formation of a number of biologically important
lipid molecules. It is well known that inhibition of MVA synthesis blocks
the cell ...
Galanin and Leu-enkephalin in the rat : with special reference to adjuvant arthritis
(2004-05-20)
In these studies, the tissue and cellular distribution of Galanin and
Leu-enkephalin were demonstrated in normal bone and joints. Furthermore,
tissue levels of Galanin and Leuenkephalin were also studied in the
ankles ...
Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C
(2001-12-31)
describes the total synthesis of circumdatin F and C, which both possess a quinazolin-4(3H)-one as well as a 1,4-benzodiazepin-5 -one moiety and incorporated L-alanine. The difference between circumdatin F and C is a hydroxyl substituent in the aromatic ring...
Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells
(2003-05-16)
induced transduction is the activation of a homologue of the Drosophila Toll receptor, termed Toll-like receptor 4 (TLR4). In addition to various signalling transduction proteins, extracellular modulators such as CD14, LBP and MD-2 are also required...
Exposure to birch pollen and development of atopic disease in childhood
(2004-01-23)
to birch pollen during pregnancy and early infancy, on the allergen-specific IgE- and IgG4-antibody (ab) response and development of atopic disease in children.
Methods: A total of 970 children with atopic heredity and born in Stockholm in 1992, 1993...
Role of toll-like receptors in host responses to mucosal bacterial infections
(2002-11-15)
the LPS receptor Toll-like receptor (TLR) 4. LPS signaling in bladder epithelial cells was indeed found to be TLR4-dependent, but the signaling also required the coreceptor sCD14. Expression of TLR4 allows rapid microbial detection but may also confer...
T lymphocyte and NK cell function in pulmonary inflammation in sarcoidosis
(2003-09-19)
The focus of this thesis is on the role of T lymphocytes and Natural Killer cells in sarcoidosis, which is an inflammatory interstitial pulmonary disorder of unknown etiology. An accumulation of CD4+ T helper cells in the lungs is a characteristic...