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T lymphocyte and NK cell function in pulmonary inflammation in sarcoidosis
(2003-09-19)
The focus of this thesis is on the role of T lymphocytes and Natural Killer cells in sarcoidosis, which is an inflammatory interstitial pulmonary disorder of unknown etiology. An accumulation of CD4+ T helper cells in the ...
Regulatory T cells : molecular and clinical aspects
(2015-01-30)
In the immune system’s tug of war with cancer, tolerance mechanisms by which the tumor can
control anti-tumor immune responses play a central role in determining the outcome.
Regulatory T cells (Treg) induced in the ...
DNA repair by HDR in experimental tumorigenesis
(2008-05-15)
The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study proteins involved in HDR is challenging since most of its members ...
Modeling PDGF-driven gliomagenesis in the mouse
(2011-09-07)
Gliomas are the most common form of brain tumors, with glioblastoma being the most aggressive form. Glioblastoma is characterized by a number of genetic aberrations, among them amplification and overexpression of ...
Risk of hepatocellular carcinoma, liver-related complications, and death in persons living with chronic hepatitis B and D
(2023-07-21)
Chronic hepatitis B virus (HBV) infection affects 257 million individuals and is a leading
cause of liver-related morbidity and mortality. Hepatitis D virus (HDV) is a satellite virus,
that needs HBV for packing and ...