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Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators
(2001-10-26)
such coactivators are the TRAP220 and the TIF2, which both contain conserved LXXLL NR interaction motifs (L, leucine; X, any amino acid), so called NR-boxes. Although they utilize the same motifs for binding to NRs, they have been shown to be components of distinct...
Health risk assessment of dioxin-like compounds in complex samples
(2003-10-10)
There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause ...
Molecular mechanisms of VEGF-mediated angiogenesis and vascular permeability
(2002-11-01)
Angiogenesis, sprouting of new capillaries from pre-existing blood vessels, is a tightly regulated multi-step process. One of the key mediators in this process is the Vascular Endothelial Growth Factor (VEGF). Many tumors ...
HIV-1 infection in Tanzania : HIV antibody testing strategies and lymphocyte subset determinations
(2003-04-16)
yearly decline of the absolute number and percentage of CD4+ T lymphocytes (CD4+%) was -21.0 cells/µl and -1.3% respectively for the HIV-1 seroprevalent subjects and -22.0 cells/µl and -1.5%, respectively for the seroincident subjects. In seroincidents...
The loss of a husband to cancer : additional and avoidable psychological traumata
(2003-05-07)
: We received 379 (75 percent) questionnaires from the widows and 220 (77 percent) from the controls. The groups (mean age 67 years) were similar on an background characteristics and by an average of three years had elapsed from the time of death...
Blood saving in orthopaedic surgery
(2002-05-10)
in orthopaedic surgery and thereby minimise transfusion requirements. In this thesis, based on 5 papers, new and established methods are studied to extend our knowledge about how to reduce blood loss in prosthetic hip and knee surgery.
In the first study (I...
Epidemiological studies of stillbirth and early neonatal death
(2002-02-15)
in case-control studies nested within the Swedish Medical Birth Register. 725 cases of stillbirth were identified among 220,712 single births to primiparous women within a geographically defined area in central Sweden between 1987 and 1996. For each case...
Identification of EBNA binding cellular proteins, using yeast two-hybrid system
(2002-12-27)
EBNA-5). Epsilon-subunit of the human chaperonin TCP-1 complex is part of a huge protein complex that helps to fold the newly synthesized polypeptides. We mapped the interacting region to the apical domain of the epsilon-subunit the most likely site...
Molecular epidemiology of human papillomavirus and cervical cancer
(2001-11-16)
/18 DNA
(OR 31,54; CI 95 % 16,41-60,62). A strong protective effect was also
found for increasing number of Pap smears during the last 5 years (OR
0,47; CI 95 % 0,35-0,62).
Conclusion: We found marked differences in determinants of exposure to
oncogenic...
Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans
(2003-05-16)
Gene expression in eukaryotic organisms commences with the synthesis of a precursor RNA, which has to be extensively processed to yield a mature RNA molecule. In addition to processing, the RNA molecule needs to associate ...