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Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators
(2001-10-26)
Nuclear receptors (NRs) are ligand-dependent transcription factors. The DNA-bound receptors either positively or negatively regulate transcription of target genes. The receptors regulate transcription through interaction ...
Determining breast cancer histological grade from RNA-sequencing data
(2017-01-16)
BACKGROUND: The histologic grade (HG) of breast cancer is an established prognostic factor. The grade is usually reported on a scale ranging from 1 to 3, where grade 3 tumours are the most aggressive. However, grade 2 is ...
Sickness absence, disability pension, and permanent medical impairment after a car crash
(2017-12-15)
Background: Road traffic injuries constitute a major public health problem worldwide. Permanent medical impairment (PMI) is used as a measure of seriousness of injuries in Sweden. There is little knowledge on consequences ...
Studies of the role of the cathelicidin peptide LL-37 in epithelial biology
(2010-05-14)
The biology of epithelial immunity as well as of tissue repair is complex and highly regulated. A variety of molecules, cell types, and biological processes such as, cell differentiation, proliferation and migration, ...
Antimicrobial peptides and pathogenic Neissera : experimental studies in mouse, man and rat
(2005-08-19)
Antimicrobial peptides are important effector molecules of innate
immunity. In this thesis, the focus is on antimicrobial peptides of the
cathelicidin family, i.e. LL-37 in man, CRAMP in mouse and rCRAMP in rat.
Expression ...