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Changes in mitogen-activated protein kinase phosphorylation and inorganic phosphate induced by skeletal muscle contraction
(2002-10-04)
in the phosphorylation of two MAP kinases, MAPK erk 1/2 and MAPKK mek1/2, were identified in response to one-leg exercise in humans. In isolated rat muscle, isometric contractions induced a similar increase in phosphorylation of MAPKerk1/2 in slow- and fast...
The rational use of drugs in a population of very old persons
(2002-02-28)
This thesis investigated the use of drugs in a population of very old
persons. The pattems of use, particularly of psychotropic drugs, and its
appropriateness were assessed. Drug use was also assessed according to
dementia ...
Candidate genes and the dopamine system : possible implications in complex neurological and psychiatric disease
(2002-04-23)
. Three different unique missense mutations were identified in patients suffering from psychosis (two in SZ, one in BD). All three mutations were located within 78 bp from each other in a region of exon 3 and disturbed NURR1-mediated transcription...
Studies on the molecular mechanisms of resistance to fluoroquinolones and carbapenems in selected bacterial species
(2003-09-05)
The emergence of mutant bacteria with multi-resistant phenotype, no longer responsive to any of the available therapeutic agents is a growing concern. We have investigated the resistance mechanisms to two classes of ...
Individual health, neighborhood characteristics, and allocation of primary health care resources
(2003-08-08)
Aims: To examine whether neighborhood education and neighborhood income predict incidence rates of coronary heart disease (CHD), beyond individual characteristics (study 1); to examine whether neighborhood deprivation, measured with Care Need Index...
On Parkinson's disease and schizophrenia : case control studies, cellular localization and modelling of candidate genes
(2003-11-21)
to study the cellular expression patterns and mRNA levels of candidate genes in SZ, PD and control brains NURR1 is one good candidate gene for disorders with an involvement of the DA neuron system since knockout mice do not develop DA neurons...
Body function and activity after acute stroke : physiotherapy perspectives
(2004-04-02)
length of stay (LOS), so as to facilitate planning of the
subsequent level of care. Study population 1.
II. We assessed 115 patients 65 years and older 10 days after stroke and
at discharge to investigate the relationship between clinically assessed...
Multiparameter flow cytometry and minimal residual disease in patients with acute leukemia
(2003-12-26)
under 0.01 % (p<0.05).
Experience from the BIOMED-1, a European Concerted Action, contributed to a MRD evaluation in a standardized way, obtained with optimal quality and sensitivity.
Two main methods of MRD detection were compared: FC with 'live...
Old age depression : occurrence and influence on cognitive functioning in aging and Alzheimer's disease
(2004-04-16)
The general aims of this thesis were to examine the occurrence of
depressive symptoms three years before the diagnoses of depression and
Alzheimer's disease (AD), and to study the effects of depression on
cognitive ...
On characterisation and diagnosis of frontotemporal lobar degeneration syndromes : with special reference to the progressive aphasias
(2002-09-19)
Alzheimer's disease (AD) is the most common dementing brain disease, with episodic memory impairment as a characteristic early feature. However, not all primary degenerative brain syndromes include prominent deficits in ...