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Candidate genes and the dopamine system : possible implications in complex neurological and psychiatric disease
(2002-04-23)
The mesencephalic dopamine (DA) system is strongly involved in the pathogenesis of Parkinsons disease (PD), where symptoms occur after the loss of the vast majority of DA neurons. An involvement of this system also in ...
Acute kidney injury, outcome studies
(2008-05-09)
Acute kidney injury (AKI) is a complex syndrome for which no effective treatment exists, and our understanding of this condition is limited. If the acute kidney injury is severe enough to require renal replacement therapy, ...
Expanding the genetic and phenotypic spectrum of skeletal dysplasias
(2018-08-17)
Skeletal dysplasias constitute a large and heterogeneous group of disorders, many causing
disabilities with profound effects on the quality of life of the affected individuals and their
families. Each individual skeletal ...
Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
(2015-08-12)
Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which ...
Premenstrual disorders : risk factors, comorbidities and health impact
(2022-05-09)
Premenstrual disorders (PMDs) are characterized by affective and physical symptoms that cyclically occur 7-10 days before the menstruation and affect millions of women of reproductive age worldwide. Despite its commonness, ...