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Regulation of mitochondrial transcription and mtDNA copy number in mammals
(2003-05-02)
for mitochondrial transcription. With the help of profile-based BLAST searches and Mtf1p peptide sequence, we were able to identify two novel mammalian mitochondrial transcription factors called TFB1M and TFB2M. Using pure recombinant mitochondrial RNA polymerase...
Molecular and functional studies of interleukin-1a in the rat testis
(2002-11-15)
The aim of the present study was to gain a better insight into the role of interleukin-1 alpha (IL-1 alpha) in testicular physiology. In testis, IL-1alpha acts as a paracrine mediator involved in the regulation of testicular functions. Bioactive IL...
HIV-1 infection in Tanzania : HIV antibody testing strategies and lymphocyte subset determinations
(2003-04-16)
The objectives of the studies that are reported in this thesis were to evaluate HIV antibody testing strategies and prognostic markers and to study inummological deterioration of HIV-1 infected individuals. Alternative testing strategies...
Characterization and modelling of CEACAM1 interactions in cell signalling
(2004-03-12)
CEACAM1, the primordial carcino-embryonic Ag gene family member, is a transmembrane cell adhesion molecule expressed in leukocytes, epithelia, and blood vessel endothelia. As a result of differential splicing, CEACAM1 occurs as several isoforms...
Preclinical studies of ribozyme-mediated gene therapy for HIV-1
(2004-05-14)
Approximately 40 million people are infected with HIV-1 and AIDS is the number one cause of death in Africa as well as, the fourth leading cause of death globally. Patients in developed countries generally receive highly active antiretroviral...
Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism
(2003-05-02)
emphasis was to characterise the interindividual variation in CYP1A2 activity with a robust phenotyping method.
Caffeine has been used to assess CYP1A2 activity. A single oral dose of 100 mg caffeine followed by a 4-hour blood and saliva sample as well...
Brain control of energy balance : localization and regulation of proteins involved in the central control of food intake and body weight
(2004-02-20)
RNA levels
in the dorsal raphe nucleus and they displayed behavioural depression,
indicating that leptin may act to regulate the brain serotonergic system.
The effect of serotonin on food intake is believed to be partly mediated
via postsynaptic 5-HT1A...
On traumatic lesion to the spinal cord and dorsal spinal roots : factors influencing axonal regrowth across the border between the central and peripheral nervous system in the rat and man
(2002-03-14)
and in the PNS.
To gain insight in how the adhesion modulating molecule tenascin might influence neuronal regeneration, the expression patterns of tenascin-R, tenascin-J1, tenascin-C and tenascin-X mRNA were analyzed in the perinatal adult rat spinal cord...
The relation of blood pressure to dementia in the elderly : a community-based longitudinal study
(2004-01-09)
with Cox
proportional hazards models. The major findings from the five research
papers included in this thesis are summarized below.
In Study I, the relationship between BP and dementia was examined.
Subjects with high systolic BP (>1 80 vs. 141-180 mm...
Gluco- and mineralocorticoid receptor regulation of regional brain neurotrophism
(2002-08-07)
fibroblast growth factor (bFGF) in CA2, CA3 and dentate gyrus together, but GR seems to act on bFGF alone in CA1 and CA4, suggesting that adrenal steroid hormones participate in the control of neurotrophic factor signaling in a highly subregion- and also...