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Pharmacokinetic studies on cladribine
(2001-11-23)
H and is deglycosylated by bacterial nucleoside phosphorylases. CdA can also be cleaved, in an enzymatic reaction in the presence of the hepatic enzyme methylthioadenosine phosphorylase, to the main metabolite 2chloroadenine (CAde). A more stable fluorinated analogue...
Respiratory drive assessment : an evaluation of the breath-by-breath occlusion pressure method in man
(2002-08-22)
A simplified concept of respiratory drive is to consider it as the integrated "output" from the CNS to the respiratory "pump" muscles. This drive is a result of a complex central respiratory pattern generation, and can in ...
Individual health, neighborhood characteristics, and allocation of primary health care resources
(2003-08-08)
(CNI), predicts CHD incidence rates, beyond individual characteristics (study 2); to examine whether low scores in a social participation index predict CHD incidence rates, after adjustment for individual characteristics (study 3); and to examine...
Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3
(2003-05-02)
processed pseudogenes whithin a 1.4 Mb comprehensive transcriptional map. We identified and characterized four novel genes: FYVE and coiled-coil domain containing 1 (FYCO1), Transmembrane protein 7 (TMEM7), Leucine-rich repeat-containing 2 (LARRC2), Leucine...
Drug use in the elderly : risk or protection? Findings from the Kungsholmen project
(2004-02-27)
, cardiac therapy agents, and
minor analgesics and antipyretics were the most commonly used drug
groups, accounting for mole than 40% of' the total medicines used. Women
used a larger number of drugs than men (3.4 vs 2.6). Anti-thrombotic
agents were...
The role of Malassezia in the pathogenesis of atopic eczema/dermatitis syndrome
(2002-01-25)
of the clones were
CD4+, and the skin-derived T-cell clones produced more Th2 cytokines than
the clones derived from blood. Furthermore, Malassezia reactive T-cell
lines could be established both from AEDS patients with Malassezia
specific serum lgE and non...
Nuclear compartmentalization of viral and cellular proteins involved in gamma-herpes virus (EBV and HHV-8) mediated cellular transformation
(2003-11-07)
in a radical redistribution of the NB-associated proteins PML, Sp100, SUMO-1 and EBNA-5 along with the proteasomes themselves. The accumulation of NB-associated proteins and proteasomes in the nucleoli of MG132-treated cells indicates...
Exposures in utero and chronic disease : an alternative methodological approach
(2002-08-30)
of 132 discordant twin pairs and 118 individual twins were obtained from birth records. In comparisons between cases and sex and age-matched external (i.e., not related) twin controls, cases had significantly lower birth weight, birth length, and head...
Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients
(2003-09-05)
regimen was studied in 132 patients (median age 54 years) with previously untreated aggressive NHL. The complete remission (CR) rate was 70% and the 5-year OS 53%. The CHOP-E regimen was an effective treatment, but mainly due to severe myelosuppression...
Respiratory control in the newborn : central chemosensitivity, neuropeptides and nicotinic effects
(2002-11-01)
. Exposure to hypercapnia also evoked expression of c-fos mRNA in several, but not all, of the areas described as chemosensitive in the adult. This may represent a maturational difference in the CO2-sensitivity. Indeed, using flow plethysmography to study...