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Crystallographic studies of gluconate kinase
(2001-11-23)
The first steps of gluconate metabolism in Escherichia coli are the transport of gluconate into the cell by a gluconate transport system, followed by phosphorylation to gluconate-6- phosphate by gluconate kinase. There exist two such different...
Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
(2002-02-08)
,2',3,4',5,5'-hexachloro-4-biphenylol (4-0H-CB146) were the most dominant congeners in blood samples, 2,2',3,4,4',5'-hexachloro-3'-biphenylol (3'-OH-CB138) and 2,2',3,3',4,5'-hexachloro-4'-biphenylol (4'OH-CB130) in liver, 3´-OH-CB138 and 2,3,3',4',5,5',6-heptachloro-4...
Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence
(2003-08-08)
in the phenotypic changes of aged motoneurons but the gp 130 cytokines continue to support motoneurons at about the same level throughout life. In the target muscles, there were a marked downregulation of IL-6 and FGF-2 mRNAs and an upregulation of FGFR1, CNTFRalpha...
Specificity of neurotrophins in the nervous system : a genetic approach to determine receptor engagement by neurotrophins
(2004-01-02)
The classical neurotrophic factor hypothesis describes the neurotrophins as retrograde signalling factors supporting the survival of postmitotic neurons during the development. Knock-out mice for the neurotrophins and/or ...
Skin sensitivity testing : a biophysical approach
(2002-04-12)
The skin is regarded as the largest organ of the body, although it is only a few millimetres thick; it is also the interface between the environment and the body's vital structures.
Its large surface area is constantly ...
Matrix degrading proteases in vascular disease
(2002-11-22)
Diverse processes of vascular disease including lesion growth, plaque rupture and abdominal aortic aneurysm formation are influenced by protease expression. Arteries undergo compensatory remodelling when the mechanical ...
Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans
(2003-05-16)
-hrp130 and showed a sequence organisation strikingly similar to the human transcriptional regulator CA150. The BR3 gene is especially rich in introns, and we suggest that Ct-hrp130, like CA150, can down-regulate transcription. This would enable splicing...
In vivo studies of cell cycle regulating proteins in rats during liver regeneration and during promotion of liver carcinogenesis
(2004-05-20)
E, p53, p 130 and pRb were increased while the levels of PCNA, cdk 2, E2F-1, -3 and -4 were decreased. Furthermore, both nuclear and cytoplasmic expression of cyclin A and -B proteins was lost.
Finally, we found that p107 a member of the Rb...
The role of exercise and exercise-related factors in the control of mitochondrial oxidative function
(2002-05-10)
,
respiratory measurements in skinned fibers were performed in an identical
medium prior to and following several types of physical activity. HI
exercise (3 bouts of cycling until fatigue at 130% of V02 max) caused a
transient decrease in the sensitivity...
Drug-resistant Mycobacterium tuberculosis in Estonia
(2003-01-31)
of TB among health care workers (HCW) in Estonia was 1.5 to 3 times higher (mean 91/100 000/year) than in the general population. In a chest hospital the incidence was 30 to 90 times higher. The highest rate was observed among physicians. In addition...