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Studies on the efficacy of potent anti-HIV-1 therapy on virological and immunological factors
(2001-08-10)
The aim of this thesis was to assess to which extent treated human
immunodeficiency virus type I (HIV-1) infected patients with a seemingly
controlled, defined as undetectable plasma HIV-1 RNA levels (< 50
copies/ml), ...
Effects of proteasome inhibitors on chondrogenesis and linear bone growth
(2013-05-07)
Linear bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and metaphysis of long bones. In the growth plate, resting/stem-like chondrocytes divide and generate the highly proliferative ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
Glucocorticoids (GCs) are widely used in both children and adults to treat common inflammatory diseases, including asthma, rheumatoid arthritis, ulcerative colitis and Crohn’s disease. However, a multitude of undesired ...
Urinary thymine dimer as a biomarker of exposure to ultraviolet radiation
(2013-03-27)
Exposure to ultraviolet radiation (UVR) is associated with all three major forms of skin cancer; squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and cutaneous malignant melanoma (CMM). Different exposure patterns ...
Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo
(2012-08-09)
Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density ...
Shoulder and upper extremity impairments, activity limitation and physiotherapeutic exercise in women with rheumatoid arthritis : a biopsychosocial approach
(2000-05-04)
The aim of this thesis was to evaluate both specially-designed and commonly used instruments for measuring impairments, activity limitation and health-related quality of life (overall Sickness Impact Profile (SIP)). The ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Family-related obesity risk factors and dietary behaviours in high-risk populations : associations with child weight development
(2014-03-12)
Background: Obesity rates in Swedish children are currently not increasing, however socioeconomic disparities are widening. Many children become obese as early as their preschool years. Hereditary and environmental ...
Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed
(2012-04-04)
Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. ...