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Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo
(2012-08-09)
Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density ...
The ubiquitin-proteasome system during proteotoxic stress
(2006-03-31)
The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under ...
Effects of helping mothers survive bleeding after birth in-service training of maternity staff : a cluster-randomized trial and mixed-method evaluation
(2020-11-06)
Background: Postpartum Haemorrhage (PPH) causes a significant amount of morbidity and mortality among mothers giving birth in sub-Saharan Africa, Tanzania included. One root cause is the insufficient health worker skills ...
Anterior cruciate ligament reconstruction : subjective knee function, graft failure and revision surgery
(2021-11-19)
An anterior cruciate ligament (ACL) tear is a severe knee injury, which leads to increased knee laxity and often functional instability. An ACL reconstruction (ACLR) is generally recommended to patients who desire to return ...
Fertility-sparing surgery in young women with ovarian cancer and borderline ovarian tumors
(2021-10-21)
Background: Based on the cell origin of the tumor, ovarian cancer (OC) is divided in epithelial ovarian cancer (EOC), including borderline ovarian tumors (BOT), and nonepithelial ovarian cancer (NEOC), which includes sex ...
Managing malaria in under-fives : prompt access, adherence to treatment and referral in rural Tanzania
(2010-11-19)
Background: Nearly a million people die of malaria each year, the majority are children in rural African settings. These deaths could be reduced if children had prompt access to artemisinin-based combination therapy (ACTs), ...
Register-based studies of sex steroid hormones and psychiatric disorders
(2023-01-27)
The focus of this thesis is the interplay between sex steroid hormones, psychiatric- and
neurodevelopmental disorders and adverse behavioral outcomes. Sex steroid hormones
are mostly known for their role in sexual ...
Studies on lupus nephritis
(2013-02-13)
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by multiple organ involvement, production of autoantibodies to nuclear components and local formation or deposition of immune ...
Skin cell heterogeneity and dynamics during morphogenesis, tissue homeostasis, and regeneration
(2021-03-31)
Skin is our protective barrier against various environmental harms. For the skin to fulfill its crucial function, it relies on multiple cell types working in concert; but most importantly it relies on skin-resident epithelial ...