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Expression and regulation of neuronal messenger molecules : focus on the NO-cGMP pathway and galanin in autonomic and sensory neurons
(2001-08-17)
stimulation, suggesting different targets for NO in various autonomic
ganglia. Using the same strategy, adrenal glands were examined. After
stimulation with a high dose of SNP (3 mM) virtually all chromaffin cells
were cGMP- immunoreactive (IR) both in rat...
Drug resistance in mycobacterium tuberculosis
(1999-10-28)
concentration of ethambutol was added. The results suggested that ß-lactams, particularly in combination with ethambutol, could be important for the treatment of MDR-TB.
An assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT...
Nuclear hormone receptors studied by molecular dynamics computer simulations
(2004-03-05)
Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. The ...
Significance of adipose tissue characteristics for development of metabolic complications in obesity
(2014-11-14)
Background: Obesity is closely related to development of insulin resistance and dyslipidemia. Intrinsic properties of adipose tissue are also of great importance for obesity related comorbidity. The aim of this thesis was ...
Community-based interventions : implications for childhood anemia prevention and control in India
(2018-08-22)
Background: Nutritional iron deficiency is the number one cause of anemia worldwide. Iron deficiency anemia has morbidity and mortality effects borne predominantly by premenopausal women and children living in South Asia ...
Physical workload and exit from the labour market : epidemiological studies with a focus on employees with musculoskeletal disorders
(2022-10-28)
, men: OR 4.04 95% CI 2.00–8.15 and women: OR 3.25 95% CI 1.81–5.83) than when summing the risks of the single exposures (study II). However, the results of the synergy index (SI) for additive interaction were not statistically significant...
Genetic aspects of HIV-1 evolution and transmission
(2008-05-02)
HIV-1 is one of the fastest evolving organisms known to man. Its rate of evolution is approximately one million times faster than that of higher organisms such as ourselves, meaning that the amount of changes within the ...
Causes and mechanisms of an adverse outcome in patients with glucose abnormalities and cardiovascular disease : epidemiological and biochemical analyses
(2016-10-26)
-based glucose control on mortality after AMI in patients with diabetes; 2. Analysing mortality and morbidity patterns after AMI in patients with newly discovered glucose abnormalities; 3. Investigating complication patterns after a first percutaneous coronary...
Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system
(2019-05-03)
The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, ...