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Calcium binding protein immunoreactivity in the central auditory system and correlations with the auditory periphery : the effects of noise and aging in mice
(2001-05-18)
This study has examined how calcium binding protein immunoreactivity is
modulated in the cochlear nucleus and the inferior colliculus after noise
exposure and during aging in mice. The effect of noise exposure ...
Studies on cytokine mRNA expression in mononuclear cells in neuroimmunological diseases
(1997-05-29)
Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), characterized by perivascular accumulation of blood mononuclear cells (MNC) and patchy demyelination. High ...
Mechanisms controlling midbrain dopaminergic neuron development
(2016-11-25)
causes the loss ofLmx1a and Ngn2 expression in the midbrain floorplate resulting in the loss of mDA progenitor specification and neurogenesis in this region. Only a few ectopic LMX1A+, NURR1 + and TH+ cells were transiently found in the basal plate...
L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia
(2014-11-07)
monophosphate (cAMP)/cAMP-dependent kinase (PKA)/ dopamine- and cAMP-regulated phosphoprotein of 32 kDA (DARPP-32) pathway. This exaggerated response results in excessive activation of the downstream extracellularregulated kinases 1 and 2 (ERK1/2) and mammalian...
Chromosomal antibiotic resistance mechanisms in Pseudomonas aeruginosa and Neisseria gonorrhoeae
(2008-03-05)
from clinically resistant strains to sensitive strain and studied the involvement of chromosomal genes gyrA, parE, porB1b and lysR by PCR and sequencing. A total of 40 cystic fibrosis isolates of P. aeruginosa were included in this study to understand...
Deuterium-L-DOPA : a novel means to improve treatment of Parkinson's disease
(2012-08-31)
L-DOPA, the precursor of dopamine, is administered to restore dopamine deficiency in Parkinson´s disease (PD) patients. L-DOPA initially provides a sustained symptomatic relief with superior efficacy as compared to other ...
Cardioplegia and cardiac function : evaluated by left ventricular pressure-volume relations
(2000-05-26)
Purpose: This thesis is focused on studies of blood cardioplegia in order to evaluate regimens of myocardial protection during cardiac surgery. To further bring down operative mortality and morbidity, in patients with ...
Environmental arsenic exposure in humans : toxicity and adaptation in the Bolivian Andes
(2021-05-07)
Arsenic, a potent toxicant and carcinogen, is naturally present in soil and leaches into groundwater. More than 140 million people worldwide are exposed to arsenic through drinking water. How well humans metabolize arsenic ...
Exploring the role of vitamin E in Alzheimer’s disease : an epidemiological and clinical perspective
(2012-05-10)
, and to predict MCI conversion to AD. The analysis of MRI and vitamin E data alone provided an accuracy of 83.2% and 92.8% respectively, for AD versus CN, and of 58.1% and 87.8% for MCI versus CN. The integrated analysis of plasma vitamin E and MRI data enhanced...