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The impact of lifestyles on the occurrence of dementia
(2001-05-09)
, or productive activity was inversely related to dementia incidence. Adjusted RRs (95% CIs) were 0.54 (0.34-0.87) for mental activities, 0.58 (0.37-0.91) for social activities and 0.58 (0.38-0.91) for productive activities. An active and socially integrated...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ...
Statistical models of breast cancer tumour progression for mammography screening data
(2018-09-17)
In this thesis we propose a novel statistical natural history model and illustrate how it can be applied to epidemiological breast cancer screening data to increase knowledge about how breast cancers progress over time and ...
Flow cytometric methods for assessment of cell-mediated immune responses
(2005-05-27)
The aim of this thesis was to develop and improve flow cytometry-based methods for assessment of cellmediated immune responses (CMI) induced by natural infection or vaccination. Traditionally, the measurement of anti ...
Mechanisms of malignant and non-malignant angiogenesis using zebrafish models
(2010-10-01)
Pathological angiogenesis significantly contribute to the onset, development and progression of most common and severe human diseases including cancer, metastatic disease, cardiovascular disease, age-related macular ...
An object's smell in the multisensory brain : how our senses interact during olfactory object processing
(2021-05-28)
Object perception is a remarkable and fundamental cognitive ability that allows us to interpret and interact with the world we are living in. In our everyday life, we constantly perceive objects–mostly without being aware ...
Learning from primary immunodeficiencies to treat cancer
(2021-09-09)
migration in DCs. In vitro assays, using microchannels and micropillars, showed that WASp-deficient DCs had increased migration speed while DCs expressing an overactive mutation in WASp, identified in X-linked neutropenia (XLN) patients, had similar average...
Assessment of dopamine and serotonin release in the non-human primate brain using PET
(2011-01-12)
The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the ...
Exploring immunotherapeutic targets in the tumor microenvironment
(2015-11-19)
The immune system has developed along with the evolution of increasingly complex
cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental
side effect of increasing organismic complexity, ...
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(2018-03-15)
The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ...