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Protein and lipid interactions of mammalian antibacterial peptides
(2001-03-09)
higher than the bactericidal concentration. An LL-37 binding protein was purified from human plasma and identified as apolipoprotein A-I (apoA-I). A KD value of 0.6-2.4 µM for the interaction between LL-37 and apoA-1 was determined, and this translates...
Aspects on the cytokine load in trauma with special reference to blood components and local versus systemic cytokine activity
(1997-03-21)
receptors I and 11 (sTNF-R 1, sTNF-R 11), IL-I receptor antagonist (IL-I ra), a soluble form of the IL-6 receptor (slL-6-R). soluble E-Selectin (sE-Selectin), soluble intercellular adhesion molecule-l (slCAM 1), and soluble vascular adhesion molecule- I (s...
Alcohol and the effect on some appetite-regulating hormones in man
(2008-11-28)
, respectively. Other gut hormones, having central effects as well as influence on intestinal motility, are glucagon-like peptide (GLP-1) and obestatin. Liver derived insulin-like growth factor-1 (IGF-1) and its binding protein insulin-like growth factor binding...
Effects of DNA damage and vesicular exchange in P. falciparum
(2019-05-28)
Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
Novel statistical methods for genome-wide association summary statistics
(2020-08-20)
A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of the ...
Mortality and co-morbidity among patients with hemochromatosis and their first-degree relatives
(2010-05-14)
Genetic hemochromatosis (GH) is an autosomal recessive disease caused by
a C282Y mutation in the HFEgene, and is characterized by excess iron
accumulation in multiple organs. Classical manifestations of GH include
liver ...
Integrative omics data analysis to discover novel signatures in complex diseases
(2023-03-09)
Apart from diseases caused by the defect of a single gene, most diseases are highly complex and are usually caused by a combination of biological and environmental factors. In the biological context, cellular processes are ...
Characterization of B cell response alterations resulting from ablation of IκBNS expression
(2020-08-07)
identified a precursor population in wildtype mice of IgM+CD93+CD19+CD5+ transitional B1a cells (TrB-1a), which exhibited other indicators of B-1 lineage commitment, such as natural IgM secretion and increased Igλ expression. We did not detect TrB-1a cells...
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(2021-02-17)
and in vitro. Both myogenic and nonmyogenic populations express ISL1, and its loss redirected myogenic progenitors into a neural-like fate. Our study provides important insights into processes during early heart development....
Poverty of opportunity for women selling sex in Lahore, Pakistan : knowledge, experiences and magnitude of HIV and STIs
(2011-05-23)
Background: According to the UNAIDS’ estimates, the incidence of HIV infection has decreased by 19% over the last ten years. WHO estimated in 2005 that approximately 448 million cases of four major curable STIs occur in ...