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Life without mitochondrial DNA : studies of transgenic mice
(2000-11-10)
).
We crossed Tfam1oxP/Tfam1oxP mice to muscle creatinine kinase (Ckmm)-cre transgenic mice to selectively disrupt Tfam in heart and skeletal muscle. Tissue-specific knockout mice (Tfam1oxP/Tfam1oxP, +/Ckmm-cre developed dilated cardiomyopathy...
Adhesion molecules and synapse remodeling during motoneuron regeneration
(2009-10-09)
resulted in altered expression of SynCAM3/necl-1 and SynCAM4/necl-4 in the nerve, which indicates possible involvement of these molecules in remyelination. SynCAM1/necl-2, SynCAM2/necl-3, and neuroligin (NLG) -2 and -3 were expressed by unlesioned...
Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease
(2005-08-10)
/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. However, there is a lack of evidence regarding tau...
Modelling and genetic correction of liver genetic diseases
(2021-03-24)
-humanized mice with hepatocytes from patients with UCD, OTC deficiency (OTCD) or carbamoyl phosphate synthetase 1 deficiency (CPS1D). Highly repopulated animals faithfully recapitulated the clinical manifestations of the disease observed in patients, including...
Inflammatory response in periodontal tissue in children with Down syndrome
(2013-05-15)
-γ), tumour necrosis factor-α (TNF-α), and interleukin (IL)-1β, IL-4, -6, -10, -12, and -17. GCF volume (μL) was significantly higher in subjects with Down syndrome (p<0.001) than controls. Mean levels of IL-1β, IL-4, IL-6, IL-10, IL-12, IFN-γ, and TNF...
TRIM21/ Ro52 in B cell pathology
(2013-01-25)
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested ...
Psychological distress and breast cancer : a bidirectional link
(2022-11-09)
was associated with a slightly increased risk of early-stage breast cancer (HR: 1.05; 95% CI: 1.02-1.08), a decreased risk of advanced-stage breast cancer (HR: 0.80; 95% CI: 0.73-0.88), and a decreased risk of breast cancer in general among women with dense...
Ultrasound-guided regional anesthesia in children and adults: aspects on central and peripheral blocks
(2012-05-03)
) was determined in 47 children receiving a high-volume (1.5 mL kg-1) caudal block in Study III. The observed spread was subsequently correlated to patient characteristics. A significant inverse relationship was found between patient characteristics and the maximal...
Do-Not-Attempt-Cardiopulmonary-Resuscitation decisions in the hospital setting
(2021-10-01)
(SRCR) from 2013 to 2104 in the Stockholm region. Outcome in study I was neurologically intact survival defined as Cerebral Performance Category score (CPC) 1 and in study II outcome was favourable neurological survival defined as CPC 1–2. Outcome...