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Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study
(2000-11-03)
Results from clinical studies and experimental investigations have given evidence of a synergistic effect when 5- fluorouracil (5-FU) has been combined with radiation or cisplatin (CDDP). From earlier experiments performed ...
Paracrine regulation of Sertoli cell proliferation
(2003-02-14)
with the important endocrine Sertoli cell regulator FSH. Furthermore, the cytokines IL-6 and IFN-gamma modulated the FSH effect in different ways. IL-6 increased, while IFN-gamma inhibited FSH-induced Sertoli cell proliferation. Bacterial endotoxin directly...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine ...
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(2010-05-28)
Coxsackievirus group B (CVB) is a common virus that usually causes only
mild symptoms in humans. However, occasionally these infections result in
severe diseases like meningitis, myocarditis and pancreatitis. In
addition, ...
Epidemiological studies of vacuum extraction delivery : incidence, risk factors and subsequent childbearing
(2014-11-10)
The aim of this thesis was to bring focus on factors and outcomes associated with vacuum
extraction delivery (VE). Delivery by VE is associated with both maternal risks (such as
obstetric anal sphincter ruptures, postpartum ...
Hematolymphoproliferative malignancies : the impact of lifestyle, organ transplantation and genetic susceptibility
(2009-01-30)
During the past decades Non-Hodgkin lymphoma (NHL) has demonstrated an
immense increase in incidence globally, among almost all age and race
groups as well as in both genders. In the search for causes, none of the
known ...
Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease
(2021-12-23)
into macrophage-like phenotypes and through regulation of macrophage-specific processes. In study II, we identified the lncRNA NUDT6, the natural antisense transcript of FGF2, to be up-regulated in fibrous caps of vulnerable vs stable plaques. NUDT6 was also up...
Chromosomal antibiotic resistance mechanisms in Pseudomonas aeruginosa and Neisseria gonorrhoeae
(2008-03-05)
The progressive increase in fluoroquinolone resistant N. gonorrhoeae and emergence of multiple antibiotic resistant P. aeruginosa are growing concerns among physicians and health policy makers. In N. gonorrhoeae chromosomal ...
Serotonin in emotional memory processes : neuropharmacological studies with emphasis on depression
(2012-02-29)
Cognitive dysfunctions are common in neuropsychiatric disorders including Major Depressive Disorder, but are difficult to normalize by antidepressant therapies and contribute to reduced functional improvement. Cognitive ...