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Tick-borne encephalitis : prognosis, immunization and virus strain characterization
(2000-10-20)
The aims were to investigate the morbidity associated with tick-borne encephalitis (TBE) both in the acute phase and at long-term follow-up, to develop a rapid neutralization test for confirmation of TBEV-specific antibody ...
Older people's home modification process
(2008-08-08)
The overall aim of the thesis was to provide theoretical and empirical
knowledge of interactions involved in the encounters between older
persons experiencing activity limitations in their home environments and
the ...
Apoptosis and inflammation regulation after injury to the developing brain
(2015-09-25)
The brain shows greater plasticity in early life than in maturity, which paradoxically renders the organ more vulnerable to hypoxia-ischemia (HI)- and cranial irradiation (IR)- induced damage. Apoptosis after a HI insult ...
Blocking interleukin-1 signalling in the brain-structural and functional outcomes
(2008-10-07)
The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform ...
Deciphering microglia plasticity in glioma
(2019-01-11)
Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can ...
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(2018-04-12)
Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway ...
Integrative omics data analysis to discover novel signatures in complex diseases
(2023-03-09)
Apart from diseases caused by the defect of a single gene, most diseases are highly complex and are usually caused by a combination of biological and environmental factors. In the biological context, cellular processes are ...
Potential mechanisms for acute health effects and lung retention of inhaled particles of different origin
(2012-05-11)
, measured lung retention was 91% at the group level. After correction for free radioactivity leaching from urine and blood samples, respectively mucociliary clearance from the central airways, the cumulative lung-particle retention was approximated to 96...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
Energy expenditure and accelerometer cut-points for sedentary behavior and physical activity in spinal cord injury : implication for guiding and prevention
(2019-09-13)
and vigorous levels of intensity, based on percentage of VO2peak, heart rate and Borg. Thus, many of the non-exercise physical activities (NEPA) were categorized as moderate or vigorous for persons with tetraplegia. Study IV showed a high correlation of 0.8-0.9...