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Studies on the interaction of human cells with transplantable materials for skin repair and cardiovascular surgery
(2000-11-17)
Tissue engineering is becoming an important field for the development of new tissues in vitro for replacement of diseased or worn out parts of the body. This thesis describes some characteristics of cultured human cells ...
Epidemiological studies on type 2 diabetes : assessment of diabetes risk factors and study participation
(2012-02-02)
Type 2 diabetes is a disease with increasing prevalence. Better knowledge of risk factors may form the bases for specific interventions and preventive measures. The aim of this thesis was to contribute to the knowledge on type 2 diabetes...
Understanding inflammatory mechanisms in rheumatic diseases
(2014-11-05)
Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
energy. AMPK activation increases glucose uptake into peripheral tissues. Even insulin-resistant individuals, including type 2 diabetes patients, retain the blood-glucose lowering effect of AMPK activation. There is a need to better understand how...
Person-centered shift handovers in oncological inpatient care
(2019-01-31)
Surveys show that patients are not sufficiently involved in decisions and planning regarding their own care, and patients have reported unfulfilled information needs in inpatient settings. To develop inpatient cancer care ...
NF-kappaB in skin immune homeostasis and cancer development
(2009-08-03)
remodulatory signature is established early, already in pre-malignant skin. This includes an accumulation of macrophages of an alternative, tumour promoting, M2 type, together with an increase in CD4+CD25+FoxP3+ regulatory T-cells. Unexpectedly, keratinocytes...
Functional and genetic studies in type 2 diabetes and obesity
(2013-11-14)
Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and mortality. The overall aim...
Somatostatin, dendritic cells and peptide T in psoriasis : a clinical, immunohistochemical and functional study
(2000-10-13)
Peptide T is an octapeptide designed to block the CD4 receptor. In a phase 1 study 9 psoriasis patients were treated with 2 mg peptide T i.v. once daily for 28 days and followed for a further 3 months. Five patients improved their PASI score >50...
Studies of the tumor-vasculature interface : role of TGF-beta 1-induced epithelial to mesenchymal transition
(2013-01-28)
Tumor metastasis is a complex multistep process. Among key steps that occur during metastatic spread are acquisition of tumor cell motility, intravasation of tumor cells into blood or lymphatic vessels and extravasation ...
Consequences of outsourcing referrals for radiological examinations
(2016-11-14)
Background: Demands for ever more effective healthcare and care accessibility for all patients continue to increase the workload in diagnostic radiology departments. Along with rapid developments in imaging technology which ...