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Somatostatin, dendritic cells and peptide T in psoriasis : a clinical, immunohistochemical and functional study
(2000-10-13)
Peptide T is an octapeptide designed to block the CD4 receptor. In a phase 1 study 9 psoriasis patients were treated with 2 mg peptide T i.v. once daily for 28 days and followed for a further 3 months. Five patients improved ...
Activating proto-oncogene mutations in human cutaneous melanoma
(2005-05-13)
Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary ...
Optimization and validation of a species-specific in vivo approach for studies on growth and progression of neural crest derived tumours
(2010-05-07)
Background: Despite great advantages in cancer therapeutics during the last decades, therapy-resistance remains a problem in the majority of malignancies. Hence, development of more effective therapeutics is critical to ...
Assessment of prognostic markers in benign and malignant melanocytic tumours
(2011-11-11)
Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past ...
Towards transcriptome-wide studies of mRNA translation in tissues from cancer patients
(2018-08-29)
Gene expression consists of multiple strictly regulated steps, including transcription, RNA modification, splicing, messenger RNA (mRNA) transport, mRNA degradation, mRNA translation and protein degradation. mRNA translation, ...