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5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2+ and ATP
(2000-09-13)
) and the subsequent dehydration to form the unstable epoxide intermediate 5(S)-trans-5,6-oxido7,9-trans-11,14-cis-eicosatetraenoic acid. The latter compound (leukotriene A4), is the precursor of the biologically active leukotrienes B4, C4, D4 and E4, which...
Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa
(2000-11-24)
Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. In compromised human, it can cause infections in urinary tract, wound and respiratory tract such as pneumonia and progressive lung diseases. Particularly the ...
Effects of bacterial toxins on calcium homeostasis in renal inflammation
(2004-04-23)
+ oscillations of this specific periodicity. Investigations of the immunostimulatory properties of the ClyA protein in TLR4-positive and -negative epithelial cell lines revealed that the ClyA toxin per se is not immuno-stimulatory, while LPS and other proteins...
Body posture and gravity as determinants of lung perfusion and ventilation
(2019-04-01)
Normal lung gas exchange depends on an intimate match between regional ventilation and regional blood flow in the lungs. The beneficial effect of the prone posture in acute respiratory failure is well documented but the ...
Proteasome targeted therapy in arthritis models : effects on pain and inflammation
(2010-09-24)
The ubiquitin proteasome system (UPS) regulates numerous cellular
functions by selectively degrading cellular proteins. It controls
activation of the transcription factor NF-ĸB which is involved in the
expression of ...
Toxicity of metal and metal oxide nanoparticles : the importance of physicochemical properties and cellular uptake
(2012-10-04)
The use of nanoparticles holds great promises in many technical as well as medical applications. However, development of new technologies, such as nanotechnology, is connected with uncertainties and risks. The same properties ...
Adolescent sexuality and sexual abuse : a Swedish perspective
(2001-05-02)
In the late 1980’s, teenage abortions and genital chlamydial infections were increasing adolescent health problems in Sweden, indicating unsafe sex practices among young people. The emergence of HIV highlighted the need ...
Ecological impact of antibiotic treatment on human normal microflora
(2013-05-20)
to the study design. The plasma concentrations of doxycycline in the doxycycline group were 0.20-1.49 mg/l. The fecal concentrations of doxycycline in the doxycycline group were 0-4.10 mg/kg. Minor effects on the oropharyngeal microflora were observed in both...
Factors associated with brain tumor risk : with focus on female sex hormones and allergic conditions
(2008-09-03)
Every year approximately 1200 people in Sweden are diagnosed with a brain
tumor. The two main histological types of brain tumors, gliomas and
meningiomas, differ in terms of their localization, histology, prognosis,
and ...
Plasmodium falciparum response to chloroquine and artemisinin based combination therapy (ACT) in Guinea-Bissau
(2009-11-06)
Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of ...