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The role of nitric oxide in porcine models of asthma and acute lung injury
(2000-11-24)
Nitric oxide (NO) is a modulator of many important physiological processes in the body. It is produced endogenously in several cell types by a family of NO synthases (NOS). The lower respiratory tract is a part of the body ...
Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment
(2014-01-10)
accordingly to the R5 and X4 phenotype. The R5 phenotype is found early in the infection while the X4 emerges over time and is associated with disease progression. The main determinant of coreceptor use in HIV-1 is the third variable region (V3) of the HIV-1...
Molecular mechanisms in synaptic vesicle recycling
(2010-09-03)
Neurons communicate through specialized contacts called synapses, which consist of pre- and postsynaptic compartments separated by a narrow synaptic cleft. The stimulus- dependent rapid influx of calcium ions into the ...
Paracrine regulation of Sertoli cell proliferation
(2003-02-14)
The Sertoli cell is a highly differentiated somatic cell in the seminiferous epithelium of the testis. This cell is of prime importance for both testicular development and spermatogenesis. Sertoli cells proliferate up to ...
Carbon-graphite fiber-reinforced polymers for implant suprastructures
(2009-04-03)
Carbon-graphite fiber-reinforced polymers (CGFR) can be used as the core material for implant-retained prostheses as an alternative to metal frameworks. The purpose was to formulate and develop carbon-graphite fiber-reinforced ...
Oxidoreductases and RNA degradosome controlling virulence-associated traits of Salmonella enterica serovar Typhimurium
(2013-09-04)
The oxidative stress response is a fundamental and primitive mode of innate immune defense in nearly all forms of life. The host oxidative stress response becomes truly important and effective especially against intracellular ...
Ultrasound and fluorescence optical imaging biomarkers for early diagnosis and prediction of rheumatoid arthritis
(2023-01-12)
Prevention of rheumatoid arthritis (RA) is most desirable together with curative treatment which is, however, not yet available. Today, the correct timely diagnosis and early treatment interventions to prevent disease ...
Delivery of DNA vaccines against cancer
(2006-10-06)
DNA vaccines against cancer have shown promising results in animal models. Efficient antigenspecific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. ...
Innate immunity in progressive multiple sclerosis
(2015-10-26)
Multiple sclerosis is (MS) is a chronic inflammatory autoimmune disease of central nervous system (CNS)
leading to demyelination, axonal damage and neurological handicap, often affecting young adults. A majority
of ...
Vascular related pathologies in cardiovascular disease and cancer
(2017-04-28)
Cardiovascular disease (CVD) and cancer are the leading causes of death worldwide. A damaged endothelium is one of the factors contributing towards these diseases. This thesis focused on understanding the implications of ...