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The role of nitric oxide in porcine models of asthma and acute lung injury
(2000-11-24)
Nitric oxide (NO) is a modulator of many important physiological processes in the body. It is produced endogenously in several cell types by a family of NO synthases (NOS). The lower respiratory tract is a part of the body ...
Let's talk about SOX : diverse key players in the transcriptional regulation of neural stem cells
(2018-05-25)
The development of the central nervous system relies on neural stem cells. How these stem cells either maintain their identity as self-renewing progenitors or differentiate into cells of the neuronal or glial lineage are ...
Multi-dimensional omics approaches to dissect natural immune control mechanisms associated with RNA virus infections
(2023-03-30)
In recent decades, global health has been challenged by emerging and re-emerging viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), human immunodeficiency viruses (HIV-1), and Crimean–Congo ...
Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer
(2019-01-24)
Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, ...
Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems
(2017-02-14)
Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). ...
Characterization of non-coding RNAs in cancer
(2014-08-25)
While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed ...