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Gene expression of selected immune regulatory molecules in neuroimmunological diseases
(2000-09-15)
Background: Multiple sclerosis (MS) is an inflammatory, demyelinating disease that is specific to the central nervous system (CNS). Myasthenia gravis (MG) is a disorder of the neuromuscular junction. Both MS and MG are ...
The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma
(2000-02-18)
Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal ...
Defining the role of migratory dendritic cells in priming T cells to mycobacteria
(2022-05-16)
Dendritic cells (DCs) are professional antigen-presenting cells that bridge innate and adaptive immunity by priming T cells. DCs residing at body surfaces such as skin sense invading microbes and respond by internalizing ...
Novel insights into dishevelled and frizzled function
(2018-10-18)
The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling ...
B cell transcriptomics and immunoglobulin genetics in rheumatoid arthritis
(2022-11-02)
Rheumatoid Arthritis (RA) is a complex autoimmune disease characterized by inflammation of the peripheral joints. The exact disease pathology remains to be elucidated, but it has been hypothesized that autoreactive B cells ...
Immunoglobulin gene usage and affinity maturation in antiviral antibodies
(2023-04-18)
The ability of antibodies to block infections makes them highly relevant for successful vaccine development. Through the papers described in this thesis, I attempt to characterize the functional and genetic aspects of ...