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Human immunodeficiency virus type 1 proteinase : regulation of function and catalytic activity
(1996-03-08)
HIV-l proteinase activity is a prerequisite for viral replication, and one of the main targets for anti-HlV therapy. Although potent proteinase inhibitors are currently being approved for treatment of AIDS patients, these ...
Insulinbehandling vid typ 1 diabetes : studier av blodglukosvariabilitet i relation till pumpbehandling, magsäckstömning och livskvalitet
(2000-11-03)
Oförutsägbara blodglukossvängningar utgör ett problem för många insulinberoende diabetespatienter och kan vara ett hinder för god sjukdomskontroll. Trots intensiva försök från patienten att fä kost insulin och motion att ...
Expression, regulation and functional aspects of the NPY Y1 receptors in rat
(2001-04-13)
The distribution of the NPY receptor subtypes, mainly of Y1 and Y2 receptors, has been studied extensively by others employing pharmacological ligand binding techniques. The major aim of this thesis was to study in detail ...
Sickness absence among patients with chronic pain in Swedish specialist healthcare
(2021-12-20)
Background: Chronic pain beyond three months is a global public health problem. Every third adult suffers from a chronic pain condition, resulting in a socioeconomic burden that corresponds to 3-10% of gross domestic product ...
Defining the role of migratory dendritic cells in priming T cells to mycobacteria
(2022-05-16)
Dendritic cells (DCs) are professional antigen-presenting cells that bridge innate and adaptive immunity by priming T cells. DCs residing at body surfaces such as skin sense invading microbes and respond by internalizing ...
Gastric bypass : positive and negative health effects
(2017-12-15)
the effect of gastric bypass surgery on diabetes type 2 treatment. 67 % of patients with diabetes treatment before surgery were without diabetes treatment 2 years after surgery and 61% after 7 years. In patients with a short duration of diabetes treatment...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine ...
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
(2011-11-02)
.05). The prevalence of SH had increased from 17% to 27% (p<0.05) and there was a slight decrease in HbA1c, 7.6% to 7.4% (p<0.05). In spite of the more frequent use of multiple injection therapy and more frequent SMBG, the prevalence of SH increased by more than 50...
The neural control of rhythmic motor sequences
(2010-10-29)
Sequence learning is one of the most important functions of the motor system since almost every advanced motor skill consists of many component movements that need to be executed in sequential order. For successful performance ...
Is it all about the money? The effects of low and high cost simulator training scenarios in surgical training
(2020-05-12)
Background: The learning process is complex and dependent on several factors such as for instance, the environment to learn, prior knowledge and distinct abilities, motivation, goal-orientation as well as the effects of ...