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The tumor suppressor gene p53 : methods for determination and their implications
(2000-10-06)
The tumor suppressor p53 plays a central part in the intracellular defense against malignant transformation and tumor progression. This, and the fact that mutations in the p53 gene are the most common genetic abnormalities ...
Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase
(2001-05-02)
Alcohol dehydrogenase 3 (ADH3), identical to glutathione-dependent formaldehyde dehydrogenase, plays a vital role in the defense against formaldehyde through the activity for the spontaneously formed adduct between ...
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(2022-04-13)
Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ...
Prenatal metabolic risks for offspring neurodevelopmental and psychiatric disorders
(2021-09-24)
obesity was associated with a markedly higher risk for any neurodevelopmental and psychiatric disorder in offspring (Hazard ratios [HR]=2.97; 95% CI, 2.23–3.96), than severe obesity (HR=1.45; 95% CI, 1.35–1.56) or PGDM (HR=1.17; 95% CI, 0.99–1.39) alone...
Radiotherapy in advanced head and neck cancer
(2023-03-17)
Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the ...
Venous thrombosis in children : the roles of vascular access and critical illness
(2022-11-18)
Venous thromboembolism (VT) is a rare event in the general pediatric population. However, the incidence in hospitalized children is higher and has increased dramatically reaching 58 per 10 000 children. The single most ...
Hemodynamics, echocardiography, and biomarkers in different heart failure phenotypes
(2020-02-12)
in cardiac output (+9.8 ± 21.6%; P = 0.026) and decrease in N-terminal pro-brain natriuretic peptide (-28.1 ± 16.3%, P < 0.001), estimated total peripheral resistance (-16.9 ± 18.3%, P = 0.004), and mean arterial pressure (-5.9 ± 8.2%, P = 0...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular ...
Getting in and out of shape : relevance for organ formation and cancer
(2014-09-11)
A central question during development is how single cells form functional multi-cellular organ structures. The high reproducibility indicates intricate synchronization of cellular behaviors such as migration, proliferation ...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
the oxidative damage. Beside mtDNA mutations that contribute to the maternal inherited diabetes (0.5-1%) several somatic mtDNA point mutations and deletions (classically associated with aging) have been described in patients with diabetes even though...