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Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs)
(2000-05-02)
Estrogens influence post-natal development and function of the female reproductive system and other organs including bone and cardiovascular system. Estrogens are also involved in the development and growth of certain ...
Associations of breast cancer risk prediction tools with tumor characteristics and metastasis
(2020-04-23)
Purpose: The association between established risk factors for breast cancer and subtypes or prognosis of the disease is not well known. We analyzed whether the Tyrer-Cuzick–predicted 10-year breast cancer risk score (TCRS), ...
Ultrasound assessment and risk prediction in women with endometrial cancer
(2020-01-09)
Background: Endometrial cancer is the most common gynecological cancer in the industrialized world, constituting 4.5% of all cancer in Swedish women. Standard surgery is hysterectomy and bilateral salpingo-oophorectomy, ...
Breast cancer natural history models and risk prediction in mammography screening cohorts
(2022-03-31)
In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
by monoenergetic electrons, and ultrasoft X-rays. For this purpose we proposed a method to sample the protein repair actions for every individual DSB, and finally calculate the total repair time for that specific DSB. The DSB-repair kinetics for the number of DSB...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of ...
Investigations of Porphyromonas gingivalis as a possible trigger of autoimmunity in the development of rheumatoid arthritis
(2018-03-29)
Rheumatoid Arthritis (RA) is a severe autoimmune disease affecting 0.5-1% worldwide. Patients suffer from pain, disability, chronic joint inflammation, comorbidities and increased mortality. Although, the aetiology of RA ...
Physical activity, body mass index and prostate cancer : studies of risk, progression and mortality
(2015-03-06)
Prostate cancer is the most common cancer among men in developed countries, but it is still
unclear what causes the disease. Body mass index (BMI) and physical activity are modifiable
lifestyle factors with the potential ...
Antibody-associated inflammation in and outside the joint in rheumatoid arthritis
(2017-08-17)
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by pain, chronic inflammation and joint destruction. Epidemiological investigations in large populationbased cohorts have identified both genetic ...
Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(2020-01-17)
The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ...