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Tetrodotoxin-resistant sodium channels in neuropathic pain
(2000-05-15)
Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. Primary ...
Gastric bypass : positive and negative health effects
(2017-12-15)
Obesity is a major health problem worldwide. It is preventable in theory, but in practice no country has been able to stop the development of increasing obesity. The only available treatment with sufficient long-term effect ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246
(2010-11-12)
The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in ...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...
Hemodynamics, echocardiography, and biomarkers in different heart failure phenotypes
(2020-02-12)
in cardiac output (+9.8 ± 21.6%; P = 0.026) and decrease in N-terminal pro-brain natriuretic peptide (-28.1 ± 16.3%, P < 0.001), estimated total peripheral resistance (-16.9 ± 18.3%, P = 0.004), and mean arterial pressure (-5.9 ± 8.2%, P = 0...
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(2020-10-08)
. In Paper II, we demonstrated that miR-375, miR-30a-3p and miR-30a-5p are regulated by Merkel cell polyomavirus (MCPyV) T-antigens through the DnaJ domain. These miRNAs could suppress autophagy and target ATG7, SQSTM1 (p62) and BECN1. Lower protein levels...