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Expression and function of ribozymes in transgenic mice
(2000-04-06)
transgenic mouse models were generated. The first transgenic mouse model, expressing a hammerhead ribozyme targeting beta-2-microglobulin (ß2-m), proved the principle that ribozymes can efficiently down-regulate the expression specific mRNAs in vivo in a...
Menopausal hormone therapy and the risk of esophageal and gastric cancer
(2017-05-24)
A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) ...
Assessment of pancreatic islet cell function and survival
(2015-05-22)
Function and survival of pancreatic islet insulin-producing beta-cells (β-cells) and glucagonproducing
alpha-cells (α-cells) were studied, and methods for this purpose were developed or
refined.
Dynamic control ...
Morphologic and genetic features of sarcomas : improving diagnosis and exploring biomarkers
(2022-08-16)
Sarcomas are malignant tumors of soft tissue and bone origin. They are a family of rare but diverse neoplasms which pose clinical challenges due to their heterogeneous properties. In order to increase our understanding of ...
Radiotherapy in advanced head and neck cancer
(2023-03-17)
be alive 5 years after diagnosis. The predominant pattern of failure is local recurrence, and this thesis addresses this problem with a focus on 1) how to treat recurrent head and neck cancer with re-irradiation, and 2) achieving improved local control...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold
(2004-09-24)
interactions with the host cell will therefore contribute both to a better understanding of cellular signaling pathways, the regulation of EBV latency and to treatment of EBV-associated malignancies. Years of LMP2A research lead to the conclusion that LMP2A...
Short-term exposure to ozone in relation to mortality and out-of-hospital cardiac arrest : exploring sensitive subgroups by previous hospitalizations
(2018-01-26)
identification numbers. Hourly values of O3 were obtained from single urban background monitoring stations in each city. We generated daily 8-h maximum levels as well as 2-h, 24-h, 2d, and 7d means. The associations between ambient O3 levels and health outcomes...
In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide
(2015-05-25)
in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. Combination chemotherapy results in complete remission in most of the patients; however, relapse occurs within 1-2 years. After relapse, more intensive treatment...
Factors associated with brain tumor risk : with focus on female sex hormones and allergic conditions
(2008-09-03)
Every year approximately 1200 people in Sweden are diagnosed with a brain
tumor. The two main histological types of brain tumors, gliomas and
meningiomas, differ in terms of their localization, histology, prognosis,
and ...