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Conserved structure-function relationships in the mediator complex
(2007-02-16)
sensitive allele srb4-138. We found that the srb4-138 allele disrupts the interaction between the head and middle domains both in vitro and in vivo. This suggested that the global shutdown of transcription in srb4-138 cells at the non-permissive temperature...
Dietary heterocyclic amines and human cancer risk
(1998-03-12)
Heterocyclic amines formed in meat during cooking are multi-site animal carcinogens and form DNA adducts in human tissues, but their relevance to human carcinogenesis has yet to be determined. The aim of this thesis was ...
Genetic studies of frontotemporal dementia : with particular emphasis on the tau gene
(2001-05-11)
Frontotemporal dementia (FTD) is next to Alzheimer's disease one of the
common causes of early onset progressive dementia. FTD is mainly
characterized by personality changes such as disinhibition, although
there are ...
Cardioplegia and cardiac function : evaluated by left ventricular pressure-volume relations
(2000-05-26)
Purpose: This thesis is focused on studies of blood cardioplegia in order to evaluate regimens of myocardial protection during cardiac surgery. To further bring down operative mortality and morbidity, in patients with ...
Differences i tropism and viral assembly pathways of human herpesvirus 6A and 6B (HHV-6A and 6B) and association of host cell proteins in HHV-6A virions
(2007-05-24)
Human herpesvirus 6A and 6B (HHV-6A and 6B) are considered to be T-lymphotropic viruses. The overall nucleotide sequence identity between the two variants is 90% and each differs by only nine variant-specific open reading frames. HHV-6A and 6B have...
Regulatory networks of c-di-GMP signalling involved in biofilm formation, motility and host pathogen interactions in Salmonella typhimurium
(2013-08-09)
Adaptation to altered environmental conditions is one of the fundamental bacterial characteristics. The ubiquitous second messenger c-di-GMP plays a key role to adopt bacterial behaviour. Transition from motility to sessility ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
The impact of Bcl-2 family members on mast cell survival and apoptosis
(2008-10-31)
Mast cells are long-lived effector cells of the immune system perhaps best known for their involvement in allergic diseases. There are several acute and chronic inflammations where mast cell accumulation, activation and ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal ...